Reaction Details | |||
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Report a problem with these data | |||
Target | Apelin receptor | ||
Ligand | BDBM360002 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | [35S]GTPgammaS Binding Assay | ||
EC50 | 2.10±n/a nM | ||
Citation | Chen, N; Chen, X; Chen, Y; Cheng, AC; Connors, RV; Deignan, J; Dransfield, PJ; Du, X; Fu, Z; Heath, JA; Horne, DB; Houze, J; Kaller, MR; Khakoo, AY; Kopecky, DJ; Lai, S; Ma, Z; McGee, LR; Medina, JC; Mihalic, JT; Nishimura, N; Olson, SH; Pattaropong, V; Swaminath, G; Wang, X; Yang, K; Yeh, W; Debenedetto, MV; Farrell, RP; Hedley, SJ; Judd, TC; Kayser, F Triazole agonists of the APJ receptor US Patent US10221162 Publication Date 3/5/2019 | ||
More Info.: | Get all data from this article, Assay Method | ||
Apelin receptor | |||
Name: | Apelin receptor | ||
Synonyms: | AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11 | ||
Type: | Enzyme Catalytic Domain | ||
Mol. Mass.: | 42664.06 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P35414 | ||
Residue: | 380 | ||
Sequence: |
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BDBM360002 | |||
n/a | |||
Name | BDBM360002 | ||
Synonyms: | (1S,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(5-methyl-3-pyridinyl)-4H-1,2,4-triazol-3- | US10221162, Example 297.0 | US10221162, Example 298.0 | US10221162, Example 299.0 | US10221162, Example 300.0 | US10221162, Example 301.0 | US10221162, Example 303.0 | ||
Type | Small organic molecule | ||
Emp. Form. | C25H30N6O5S2 | ||
Mol. Mass. | 558.673 | ||
SMILES | CO[C@@H]([C@@H](C)S(=O)(=O)Nc1nnc(-c2cncc(C)c2)n1-c1c(OC)cccc1OC)c1nc(C)c(C)s1 |r,wU:2.1,wD:3.3,(-5.81,-10.75,;-6.96,-9.72,;-6.64,-8.21,;-7.78,-7.18,;-7.46,-5.67,;-9.25,-7.65,;-10.02,-8.99,;-8.48,-8.99,;-10.39,-6.62,;-11.85,-7.1,;-12.33,-8.56,;-13.87,-8.56,;-14.35,-7.1,;-15.89,-7.1,;-16.66,-8.43,;-18.2,-8.43,;-18.97,-7.1,;-18.2,-5.77,;-18.97,-4.43,;-16.66,-5.77,;-13.1,-6.19,;-13.1,-4.65,;-14.43,-3.88,;-15.77,-4.65,;-17.1,-3.88,;-14.43,-2.34,;-13.1,-1.57,;-11.77,-2.34,;-11.77,-3.88,;-10.43,-4.65,;-9.1,-3.88,;-5.17,-7.73,;-3.93,-8.64,;-2.68,-7.73,;-1.22,-8.21,;-3.16,-6.27,;-2.25,-5.02,;-4.7,-6.27,)| | ||
Structure |