Reaction Details |
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Target | Neuraminidase |
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Ligand | BDBM5245 |
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Substrate/Competitor | BDBM4702 |
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Meas. Tech. | Neuraminidase Inhibition Assay |
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IC50 | 160000±n/a nM |
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Citation | Zhang, L; Williams, MA; Mendel, DB; Escarpe, PA; Chen, X; Wang, KY; Graves, BJ; Lawton, G; Kim, CU Synthesis and evaluation of 1,4,5,6-tetrahydropyridazine derivatives as influenza neuraminidase inhibitors. Bioorg Med Chem Lett9:1751-6 (1999) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Neuraminidase |
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Name: | Neuraminidase |
Synonyms: | Influenza A Virus Neuraminidase | NA | NRAM_I34A1 | Neuraminidase | Neuraminidase A |
Type: | Enzyme |
Mol. Mass.: | 50124.14 |
Organism: | Influenza A virus (A/Puerto Rico/8/34/Mount Sinai(H1N1)) |
Description: | P03468 |
Residue: | 454 |
Sequence: | MNPNQKIITIGSICLVVGLISLILQIGNIISIWISHSIQTGSQNHTGICNQNIITYKNST
WVKDTTSVILTGNSSLCPIRGWAIYSKDNSIRIGSKGDVFVIREPFISCSHLECRTFFLT
QGALLNDKHSNGTVKDRSPYRALMSCPVGEAPSPYNSRFESVAWSASACHDGMGWLTIGI
SGPDNGAVAVLKYNGIITETIKSWRKKILRTQESECACVNGSCFTIMTDGPSDGLASYKI
FKIEKGKVTKSIELNAPNSHYEECSCYPDTGKVMCVCRDNWHGSNRPWVSFDQNLDYQIG
YICSGVFGDNPRPEDGTGSCGPVYVDGANGVKGFSYRYGNGVWIGRTKSHSSRHGFEMIW
DPNGWTETDSKFSVRQDVVAMTDWSGYSGSFVQHPELTGLDCMRPCFWVELIRGRPKEKT
IWTSASSISFCGVNSDTVDWSWPDGAELPFSIDK
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BDBM5245 |
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BDBM4702 |
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Name | BDBM5245 |
Synonyms: | (5R,6S)-5-amino-6-acetamido-1-(2-ethylbutanoyl)-1,4,5,6-tetrahydropyridazine-3-carboxylic acid | Tetrahydropyridazine deriv. 19 |
Type | Small organic molecule |
Emp. Form. | C13H22N4O4 |
Mol. Mass. | 298.3382 |
SMILES | CCC(CC)C(=O)N1N=C(C[C@@H](N)[C@H]1NC(C)=O)C(O)=O |r,c:8| |
Structure |
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