| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Beta-lactamase |
|---|
| Ligand | BDBM36640 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Metallo-Beta-Lactamase Assay |
|---|
| pH | 7±0 |
|---|
| Temperature | 310.15±0 K |
|---|
| IC50 | 1.9e+3± 2e+2 nM |
|---|
| Citation |  Toney, JH; Fitzgerald, PM; Grover-Sharma, N; Olson, SH; May, WJ; Sundelof, JG; Vanderwall, DE; Cleary, KA; Grant, SK; Wu, JK; Kozarich, JW; Pompliano, DL; Hammond, GG Antibiotic sensitization using biphenyl tetrazoles as potent inhibitors of Bacteroides fragilis metallo-beta-lactamase. Chem Biol5:185-96 (1998) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Beta-lactamase |
|---|
| Name: | Beta-lactamase |
|---|
| Synonyms: | Metallo-beta-lactamase |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 27160.75 |
|---|
| Organism: | Bacteroides fragilis |
|---|
| Description: | Q8KZP2 |
|---|
| Residue: | 249 |
|---|
| Sequence: | MKTVFILISMLFPVAVMAQKSVKISDDISITQLSDKVYTYVSLAEIEGWGMVPSNGMIVI
NNHQAALLDTPINDAQTETLVNWVADSLHAKVTTFIPNHWHGDCIGGLGYLQKKGVQSYA
NQMTIDLAKEKGLPVPEHGFTDSLTVSLDGMPLQCYYLGGGHATDNIVVWLPTENILFGG
CMLKDNQATSIGNISDADVTAWPKTLDKVKAKFPSARYVVPGHGDYGGTELIEHPKQIVN
QYIESTSKP
|
|
|
|---|
| BDBM36640 |
|---|
| n/a |
|---|
| Name | BDBM36640 |
|---|
| Synonyms: | CHEMBL26514 | L-159,061 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H24N6O2 |
|---|
| Mol. Mass. | 452.5078 |
|---|
| SMILES | CCCCc1nc2ccc(O)cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1 |
|---|
| Structure | 
|
|---|
Search and Browse
