Reaction Details | |||
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Target | Cyclin-dependent kinase 5 activator 1 | ||
Ligand | BDBM50261188 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1695674 (CHEMBL4046564) | ||
IC50 | 90±n/a nM | ||
Citation | Park, SJ; Kim, E; Yoo, M; Lee, JY; Park, CH; Hwang, JY; Ha, JD Synthesis and biological evaluation of N9-cis-cyclobutylpurine derivatives for use as cyclin-dependent kinase (CDK) inhibitors. Bioorg Med Chem Lett27:4399-4404 (2017) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Cyclin-dependent kinase 5 activator 1 | |||
Name: | Cyclin-dependent kinase 5 activator 1 | ||
Synonyms: | CDK5/p35 | Cyclin-Dependent Kinase 5 (CDK5) | Cyclin-dependent kinase 5 regulatory subunit 1 | Cyclin-dependent kinase 5/CDK5 activator 1 | ||
Type: | Protein Complex | ||
Mol. Mass.: | n/a | ||
Description: | n/a | ||
Components: | This complex has 2 components. | ||
Component 1 | |||
Name: | Cyclin-dependent kinase 5 | ||
Synonyms: | CDK5 | CDK5_HUMAN | CDKN5 | Cell division protein kinase 5 | Cyclin-dependent kinase 5 (CDK5/ p25) | Cyclin-dependent kinase 5 (CDK5/p35) | Cyclin-dependent-like kinase 5 | Cyclin-dependent-like kinase 5 (CDK5) | PSSALRE | Serine/threonine-protein kinase PSSALRE | Tau protein kinase II catalytic subunit | ||
Type: | Enzyme Subunit | ||
Mol. Mass.: | 33308.61 | ||
Organism: | Homo sapiens (Human) | ||
Description: | n/a | ||
Residue: | 292 | ||
Sequence: |
| ||
Component 2 | |||
Name: | Cyclin-dependent kinase 5 activator 1 | ||
Synonyms: | CD5R1_HUMAN | CDK5R | CDK5R1 | Cyclin-Dependent Kinase 5 Activator 1, p35 | Cyclin-dependent kinase 5 (CDK5/p25) | Cyclin-dependent kinase 5 regulatory subunit 1 | NCK5A | TPKII regulatory subunit | p35 | ||
Type: | Enzyme Subunit | ||
Mol. Mass.: | 34077.43 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q15078 | ||
Residue: | 307 | ||
Sequence: |
| ||
BDBM50261188 | |||
n/a | |||
Name | BDBM50261188 | ||
Synonyms: | CHEMBL4098980 | ||
Type | Small organic molecule | ||
Emp. Form. | C27H36N8O3 | ||
Mol. Mass. | 520.6265 | ||
SMILES | Cc1cccc(n1)C(=O)N[C@H]1C[C@H](C1)n1cnc2c(NCC3CCN(CC3)C(=O)OC(C)(C)C)ncnc12 |r,wU:12.15,10.10,(33.46,-18.55,;32.37,-19.63,;30.88,-19.22,;29.79,-20.32,;30.18,-21.8,;31.67,-22.2,;32.76,-21.12,;32.06,-23.69,;33.56,-24.01,;31.02,-24.84,;29.51,-24.51,;28.22,-25.33,;27.39,-24.04,;28.69,-23.22,;25.88,-23.71,;25.26,-22.31,;23.73,-22.46,;23.4,-23.97,;22.07,-24.74,;20.74,-23.96,;19.41,-24.73,;18.07,-23.95,;18.08,-22.41,;16.75,-21.64,;15.41,-22.4,;15.41,-23.94,;16.73,-24.72,;14.08,-21.63,;14.09,-20.09,;12.74,-22.39,;11.41,-21.62,;10.08,-20.84,;11.42,-20.09,;10.08,-22.38,;22.06,-26.28,;23.39,-27.05,;24.73,-26.29,;24.74,-24.75,)| | ||
Structure |