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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Cyclin-A2/Cyclin-dependent kinase 2 | ||
| Ligand | BDBM50261188 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1695672 (CHEMBL4046562) | ||
| IC50 | 376±n/a nM | ||
| Citation |  Park, SJ; Kim, E; Yoo, M; Lee, JY; Park, CH; Hwang, JY; Ha, JD Synthesis and biological evaluation of N9-cis-cyclobutylpurine derivatives for use as cyclin-dependent kinase (CDK) inhibitors. Bioorg Med Chem Lett27:4399-4404 (2017) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Cyclin-A2/Cyclin-dependent kinase 2 | |||
| Name: | Cyclin-A2/Cyclin-dependent kinase 2 | ||
| Synonyms: | CDK2-CyclinA | CDK2/A | CDK2/Cyclin A | CDK2/Cyclin A2 | Cyclin A2/dependent kinase 2 | Cyclin-Dependent Kinase 2 (CDK2) | Cyclin-Dependent Kinase 2 (CDK2A) | ||
| Type: | Protein Complex | ||
| Mol. Mass.: | n/a | ||
| Description: | Cdk2/Cyclin A kinase was purified from insect cells coinfected with Cyclin A/Cdk2 baculovirus. | ||
| Components: | This complex has 2 components. | ||
| Component 1 | |||
| Name: | Cyclin-dependent kinase 2 | ||
| Synonyms: | CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase | ||
| Type: | Enzyme Subunit | ||
| Mol. Mass.: | 33938.17 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P24941 | ||
| Residue: | 298 | ||
| Sequence: |
| ||
| Component 2 | |||
| Name: | Cyclin-A2 | ||
| Synonyms: | CCN1 | CCNA | CCNA1 | CCNA2 | CCNA2_HUMAN | Cyclin A | Cyclin-A | ||
| Type: | Enzyme Subunit | ||
| Mol. Mass.: | 48550.19 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P20248 | ||
| Residue: | 432 | ||
| Sequence: |
| ||
| BDBM50261188 | |||
| n/a | |||
| Name | BDBM50261188 | ||
| Synonyms: | CHEMBL4098980 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C27H36N8O3 | ||
| Mol. Mass. | 520.6265 | ||
| SMILES | Cc1cccc(n1)C(=O)N[C@H]1C[C@H](C1)n1cnc2c(NCC3CCN(CC3)C(=O)OC(C)(C)C)ncnc12 |r,wU:12.15,10.10,(33.46,-18.55,;32.37,-19.63,;30.88,-19.22,;29.79,-20.32,;30.18,-21.8,;31.67,-22.2,;32.76,-21.12,;32.06,-23.69,;33.56,-24.01,;31.02,-24.84,;29.51,-24.51,;28.22,-25.33,;27.39,-24.04,;28.69,-23.22,;25.88,-23.71,;25.26,-22.31,;23.73,-22.46,;23.4,-23.97,;22.07,-24.74,;20.74,-23.96,;19.41,-24.73,;18.07,-23.95,;18.08,-22.41,;16.75,-21.64,;15.41,-22.4,;15.41,-23.94,;16.73,-24.72,;14.08,-21.63,;14.09,-20.09,;12.74,-22.39,;11.41,-21.62,;10.08,-20.84,;11.42,-20.09,;10.08,-22.38,;22.06,-26.28,;23.39,-27.05,;24.73,-26.29,;24.74,-24.75,)| | ||
| Structure | 
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