Reaction Details |
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Target | Genome polyprotein |
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Ligand | BDBM50274118 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1713933 (CHEMBL4123982) |
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IC50 | 6600±n/a nM |
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Citation | Wang, G; Lim, SP; Chen, YL; Hunziker, J; Rao, R; Gu, F; Seh, CC; Ghafar, NA; Xu, H; Chan, K; Lin, X; Saunders, OL; Fenaux, M; Zhong, W; Shi, PY; Yokokawa, F Structure-activity relationship of uridine-based nucleoside phosphoramidate prodrugs for inhibition of dengue virus RNA-dependent RNA polymerase. Bioorg Med Chem Lett28:2324-2327 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Genome polyprotein |
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Name: | Genome polyprotein |
Synonyms: | Nonstructural protein 5 |
Type: | PROTEIN |
Mol. Mass.: | 102978.18 |
Organism: | Dengue virus |
Description: | ChEMBL_117874 |
Residue: | 900 |
Sequence: | GTGNTGETLGEKWKNRLNSLGKSEFQIYKRSGIQEVDRTLAKEGIKRGETDHHAVSRGSA
KLRWFVERNLVTPEGKVVDLGCGRGGWSYYCGGLKNVREVRGLTKGGPGHEEPIPMSTYG
WNLVRLQSGVDVFFTPPEKCDTLLCDIGESSPNPTVEAGRTLRVLNLVENWLNNNTQFCI
KVLNPYMPSVIEKMETLQRKYGGALVRNPLSRNSTHEMYWVSNASGNIVSSVNMISRMLI
NRFTMRHKKATYEPDVDLGSGTRNIGIESETPNLDIIGKRIEKIKQEHETSWHYDQDHPY
KTWAYHGSYETKQTGSASSVVNGVVRLLTKPWDVIPMVTQMAMTDTTPFGQQRVFKEKVD
TRTQEPKEGTKKLMKITAEWLWKELGKKKTPRMCTREEFARKVRSNAALGAIFTDENKWK
SAREAVEDSRFWELVDKERNLHLEGKCETCVYNMMGKREKKIGEFGKAKGSRAVWYMWLG
ARFLEFEALGFLNEDHWFSRENSLSGVEGEGLHKLGYILREVSKKEGGAMYADDTAGWDT
RITLEDLKNEEMVTNHMEGEHKKLAEAIFKLTYQNKVVRVQRPTPRGTVMDIISRRDQRS
SGQVGTYGLNTFTNMGAQLIRQMEGEGVFKGIQHLTATEEVAVQDWLARVGRERLSRMAI
SGDDCVVKPLDDRFASALTALNDMGKVRKDIQQWEPSRGWNDWTQVPFCSHHFHELIMKD
GRVLVVPCRNQDELIGRARISQGAGWSLRETACLGKSYAQMWSLMYFHRRGLRLAANAIC
SAVPSHWVPTSRTTWSIHARHEWMTTEDMLTVWNRVWIQENPWMEDKTPVESWEEIPYLG
KRGDQWCGSLIGLTSRATWARNIQTAINRVRSLIGSEGYTDYMPSMKRFRREEDEAGVLW
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BDBM50274118 |
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n/a |
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Name | BDBM50274118 |
Synonyms: | CHEMBL4127030 | US10793591, Compound 7a |
Type | Small organic molecule |
Emp. Form. | C10H16FN2O15P3 |
Mol. Mass. | 516.1581 |
SMILES | C[C@@]1(O)[C@H](O)[C@@](F)(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]1n1ccc(=O)[nH]c1=O |r| |
Structure |
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