Reaction Details |
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Target | Reverse transcriptase |
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Ligand | BDBM50292206 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1731684 (CHEMBL4147220) |
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IC50 | 58±n/a nM |
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Citation | Jin, K; Yin, H; De Clercq, E; Pannecouque, C; Meng, G; Chen, F Discovery of biphenyl-substituted diarylpyrimidines as non-nucleoside reverse transcriptase inhibitors with high potency against wild-type and mutant HIV-1. Eur J Med Chem145:726-734 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Reverse transcriptase |
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Name: | Reverse transcriptase |
Synonyms: | n/a |
Type: | Protein |
Mol. Mass.: | 29598.37 |
Organism: | Human immunodeficiency virus 1 |
Description: | Q9WKE8 |
Residue: | 254 |
Sequence: | PISPITVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKIEKIGPENPYNTPVF
AIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLD
KDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIY
QYMDDLYVGSDLEIEQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTV
QPIVLPEKDSWTVN
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BDBM50292206 |
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n/a |
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Name | BDBM50292206 |
Synonyms: | CHEMBL4161215 |
Type | Small organic molecule |
Emp. Form. | C26H20F3N5 |
Mol. Mass. | 459.4657 |
SMILES | Cc1cc(cc(C)c1Nc1ccnc(Nc2ccc(cc2)C#N)n1)-c1cccc(c1)C(F)(F)F |
Structure |
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