| Reaction Details |
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 | Report a problem with these data |
| Target | Nuclear receptor ROR-beta |
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| Ligand | BDBM50367063 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1735691 (CHEMBL4151227) |
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| IC50 | >20000±n/a nM |
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| Citation |  Nishiyama, Y; Mori, S; Makishima, M; Fujii, S; Kagechika, H; Hashimoto, Y; Ishikawa, M Novel Nonsteroidal Progesterone Receptor (PR) Antagonists with a Phenanthridinone Skeleton. ACS Med Chem Lett9:641-645 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Nuclear receptor ROR-beta |
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| Name: | Nuclear receptor ROR-beta |
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| Synonyms: | NR1F2 | Nuclear receptor RZR-beta | Nuclear receptor subfamily 1 group F member 2 | RORB | RORB_HUMAN | RZRB | Retinoid-related orphan receptor-beta |
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| Type: | PROTEIN |
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| Mol. Mass.: | 53227.30 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_107979 |
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| Residue: | 470 |
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| Sequence: | MCENQLKTKADATAQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQNNASYSCPRQ
RNCLIDRTNRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLYAEVQKHQQRLQEQRQ
QQSGEAEALARVYSSSISNGLSNLNNETSGTYANGHVIDLPKSEGYYNVDSGQPSPDQSG
LDMTGIKQIKQEPIYDLTSVPNLFTYSSFNNGQLAPGITMTEIDRIAQNIIKSHLETCQY
TMEELHQLAWQTHTYEEIKAYQSKSREALWQQCAIQITHAIQYVVEFAKRITGFMELCQN
DQILLLKSGCLEVVLVRMCRAFNPLNNTVLFEGKYGGMQMFKALGSDDLVNEAFDFAKNL
CSLQLTEEEIALFSSAVLISPDRAWLIEPRKVQKLQEKIYFALQHVIQKNHLDDETLAKL
IAKIPTITAVCNLHGEKLQVFKQSHPEIVNTLFPPLYKELFNPDCATGCK
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| BDBM50367063 |
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| n/a |
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| Name | BDBM50367063 |
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| Synonyms: | CHEMBL4174199 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H11F6NO2 |
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| Mol. Mass. | 375.2652 |
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| SMILES | Cc1cc(cc2c1[nH]c(=O)c1ccccc21)C(O)(C(F)(F)F)C(F)(F)F |
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| Structure | 
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