| Reaction Details |
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 | Report a problem with these data |
| Target | Reverse transcriptase protein |
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| Ligand | BDBM50483706 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_741510 (CHEMBL1769293) |
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| IC50 | 117±n/a nM |
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| Citation |  La Regina, G; Coluccia, A; Brancale, A; Piscitelli, F; Gatti, V; Maga, G; Samuele, A; Pannecouque, C; Schols, D; Balzarini, J; Novellino, E; Silvestri, R Indolylarylsulfones as HIV-1 non-nucleoside reverse transcriptase inhibitors: new cyclic substituents at indole-2-carboxamide. J Med Chem54:1587-98 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Reverse transcriptase protein |
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| Name: | Reverse transcriptase protein |
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| Synonyms: | Reverse Transcriptase | Reverse Transcriptase (A62V) | Reverse Transcriptase (F61A) |
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| Type: | Protein |
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| Mol. Mass.: | 30203.56 |
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| Organism: | Human immunodeficiency virus 1 |
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| Description: | Q9WJQ2 |
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| Residue: | 259 |
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| Sequence: | PISPIEPVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKRSVTVLDVGDAYFSVPL
DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLKWGFTTPDKKHQKEPPFLWMGYEHHPDKWT
VQPIVLPEKDSWTVNDIQK
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| BDBM50483706 |
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| n/a |
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| Name | BDBM50483706 |
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| Synonyms: | CHEMBL1766217 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H24ClN3O4S |
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| Mol. Mass. | 461.962 |
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| SMILES | Cc1cc(C)cc(c1)S(=O)(=O)c1c([nH]c2ccc(Cl)cc12)C(=O)NCN1CCOCC1 |
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| Structure | 
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