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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Interleukin-1 receptor-associated kinase 4 | ||
| Ligand | BDBM50499203 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1538243 (CHEMBL3737182) | ||
| Ki | 0.420000±n/a nM | ||
| Citation |  Wang, Z; Sun, D; Johnstone, S; Cao, Z; Gao, X; Jaen, JC; Liu, J; Lively, S; Miao, S; Sudom, A; Tomooka, C; Walker, NP; Wright, M; Yan, X; Ye, Q; Powers, JP Discovery of potent, selective, and orally bioavailable inhibitors of interleukin-1 receptor-associate kinase-4. Bioorg Med Chem Lett25:5546-50 (2015) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Interleukin-1 receptor-associated kinase 4 | |||
| Name: | Interleukin-1 receptor-associated kinase 4 | ||
| Synonyms: | IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64 | ||
| Type: | Protein | ||
| Mol. Mass.: | 51519.08 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q9NWZ3 | ||
| Residue: | 460 | ||
| Sequence: |
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| BDBM50499203 | |||
| n/a | |||
| Name | BDBM50499203 | ||
| Synonyms: | CHEMBL3736036 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C28H33F3N4O2 | ||
| Mol. Mass. | 514.5824 | ||
| SMILES | OC[C@H]1CC[C@H](CC1)n1c(NC(=O)c2cccc(c2)C(F)(F)F)nc2cc(CN3CCCCC3)ccc12 |r,wD:5.8,2.1,(4.54,-7.52,;3.36,-7.18,;2.98,-5.68,;4.09,-4.62,;3.72,-3.12,;2.24,-2.7,;1.13,-3.76,;1.5,-5.26,;1.76,-1.24,;2.66,.02,;4.2,.04,;4.95,1.38,;4.32,2.44,;6.49,1.4,;7.24,2.75,;8.78,2.76,;9.57,1.44,;8.82,.1,;7.28,.08,;9.6,-1.23,;10.83,-1.22,;9,-2.3,;10.23,-2.29,;1.76,1.24,;.3,.77,;-1.03,1.55,;-2.38,.77,;-3.72,1.53,;-5.05,.74,;-6.39,1.5,;-7.71,.72,;-7.7,-.82,;-6.36,-1.58,;-5.03,-.8,;-2.38,-.77,;-1.03,-1.55,;.3,-.77,)| | ||
| Structure | 
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