| Reaction Details |
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 | Report a problem with these data |
| Target | Stromelysin-1 |
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| Ligand | BDBM50063137 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_104905 (CHEMBL713441) |
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| IC50 | >1000±n/a nM |
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| Citation |  Tamura, Y; Watanabe, F; Nakatani, T; Yasui, K; Fuji, M; Komurasaki, T; Tsuzuki, H; Maekawa, R; Yoshioka, T; Kawada, K; Sugita, K; Ohtani, M Highly selective and orally active inhibitors of type IV collagenase (MMP-9 and MMP-2): N-sulfonylamino acid derivatives. J Med Chem41:640-9 (1998) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Stromelysin-1 |
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| Name: | Stromelysin-1 |
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| Synonyms: | MMP-3 | MMP3 | MMP3_HUMAN | Matrix metalloproteinase (2 and 3) | Matrix metalloproteinase 3 | Matrix metalloproteinase-3 | Matrix metalloproteinase-3 (MMP-3) | Matrix metalloproteinase-3 (MMP3) | SL-1 | STMY1 | Stromelysin 1 | Transin-1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 53973.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P08254 |
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| Residue: | 477 |
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| Sequence: | MKSLPILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLKKDVKQFVRRKDSGPV
VKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYRIVN
YTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNV
LAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLY
HSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAVS
TLRGEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQF
WAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEP
GFPKQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC
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| BDBM50063137 |
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| n/a |
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| Name | BDBM50063137 |
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| Synonyms: | (R)-3-Methyl-2-{4-[2-(4-methylsulfanyl-phenyl)-2H-tetrazol-5-yl]-benzenesulfonylamino}-butyric acid | CHEMBL160153 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H21N5O4S2 |
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| Mol. Mass. | 447.531 |
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| SMILES | CSc1ccc(cc1)-n1nnc(n1)-c1ccc(cc1)S(=O)(=O)N[C@H](C(C)C)C(O)=O |
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| Structure | 
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