Compile Data Set for Download or QSAR

Found 170 hits with Last Name = 'tsuzuki' and Initial = 'h'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Matrix metalloproteinase-9 (Homo sapiens (Human))	BDBM8485 ((2R)-N-hydroxy-3-methyl-2-[(4-phenoxybenzene)sulfo...) Show SMILES CC(C)[C@@H](NS(=O)(=O)c1ccc(Oc2ccccc2)cc1)C(=O)NO |r| Show InChI InChI=1S/C17H20N2O5S/c1-12(2)16(17(20)18-21)19-25(22,23)15-10-8-14(9-11-15)24-13-6-4-3-5-7-13/h3-12,16,19,21H,1-2H3,(H,18,20)/t16-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.540	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against human gelatinase B (Matrix metalloproteinase-9)				J Med Chem 41: 640-9 (1998) Article DOI: 10.1021/jm9707582 BindingDB Entry DOI: 10.7270/Q2HD7TS9
					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50077162 ((R)-3-(1H-Indol-3-yl)-2-[4-(4-methoxy-phenylethyny...) Show SMILES COc1ccc(cc1)C#Cc1ccc(cc1)S(=O)(=O)N[C@H](Cc1c[nH]c2ccccc12)C(O)=O Show InChI InChI=1S/C26H22N2O5S/c1-33-21-12-8-18(9-13-21)6-7-19-10-14-22(15-11-19)34(31,32)28-25(26(29)30)16-20-17-27-24-5-3-2-4-23(20)24/h2-5,8-15,17,25,27-28H,16H2,1H3,(H,29,30)/t25-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.650	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Company, Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against Matrix metalloproteinase-2 (concentration required for 50% inhibition of enzyme activity)				J Med Chem 42: 1723-38 (1999) Article DOI: 10.1021/jm980514x BindingDB Entry DOI: 10.7270/Q2KP81BQ
					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50063148 ((R)-2-(Biphenyl-4-sulfonylamino)-N-hydroxy-3-(1H-i...) Show SMILES ONC(=O)[C@@H](Cc1c[nH]c2ccccc12)NS(=O)(=O)c1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C23H21N3O4S/c27-23(25-28)22(14-18-15-24-21-9-5-4-8-20(18)21)26-31(29,30)19-12-10-17(11-13-19)16-6-2-1-3-7-16/h1-13,15,22,24,26,28H,14H2,(H,25,27)/t22-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against human gelatinase A (matrix metalloproteinase-2 MMP2)				J Med Chem 41: 640-9 (1998) Article DOI: 10.1021/jm9707582 BindingDB Entry DOI: 10.7270/Q2HD7TS9
					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50077157 ((R)-2-[5-(4-Ethyl-phenylethynyl)-thiophene-2-sulfo...) Show SMILES CCc1ccc(cc1)C#Cc1ccc(s1)S(=O)(=O)N[C@H](Cc1c[nH]c2ccccc12)C(O)=O Show InChI InChI=1S/C25H22N2O4S2/c1-2-17-7-9-18(10-8-17)11-12-20-13-14-24(32-20)33(30,31)27-23(25(28)29)15-19-16-26-22-6-4-3-5-21(19)22/h3-10,13-14,16,23,26-27H,2,15H2,1H3,(H,28,29)/t23-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Company, Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against Matrix metalloproteinase-2 (concentration required for 50% inhibition of enzyme activity)				J Med Chem 42: 1723-38 (1999) Article DOI: 10.1021/jm980514x BindingDB Entry DOI: 10.7270/Q2KP81BQ
					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50063129 ((R)-3-(1H-Indol-3-yl)-2-(5-p-tolylethynyl-thiophen...) Show SMILES Cc1ccc(cc1)C#Cc1ccc(s1)S(=O)(=O)N[C@H](Cc1c[nH]c2ccccc12)C(O)=O Show InChI InChI=1S/C24H20N2O4S2/c1-16-6-8-17(9-7-16)10-11-19-12-13-23(31-19)32(29,30)26-22(24(27)28)14-18-15-25-21-5-3-2-4-20(18)21/h2-9,12-13,15,22,25-26H,14H2,1H3,(H,27,28)/t22-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Company, Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against Matrix metalloproteinase-2 (concentration required for 50% inhibition of enzyme activity)				J Med Chem 42: 1723-38 (1999) Article DOI: 10.1021/jm980514x BindingDB Entry DOI: 10.7270/Q2KP81BQ
					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM8485 ((2R)-N-hydroxy-3-methyl-2-[(4-phenoxybenzene)sulfo...) Show SMILES CC(C)[C@@H](NS(=O)(=O)c1ccc(Oc2ccccc2)cc1)C(=O)NO |r| Show InChI InChI=1S/C17H20N2O5S/c1-12(2)16(17(20)18-21)19-25(22,23)15-10-8-14(9-11-15)24-13-6-4-3-5-7-13/h3-12,16,19,21H,1-2H3,(H,18,20)/t16-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against human gelatinase A (matrix metalloproteinase-2 MMP2)				J Med Chem 41: 640-9 (1998) Article DOI: 10.1021/jm9707582 BindingDB Entry DOI: 10.7270/Q2HD7TS9
					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50063139 ((R)-2-[4-(4-Bromo-benzoylamino)-benzenesulfonylami...) Show SMILES OC(=O)[C@@H](Cc1c[nH]c2ccccc12)NS(=O)(=O)c1ccc(NC(=O)c2ccc(Br)cc2)cc1 Show InChI InChI=1S/C24H20BrN3O5S/c25-17-7-5-15(6-8-17)23(29)27-18-9-11-19(12-10-18)34(32,33)28-22(24(30)31)13-16-14-26-21-4-2-1-3-20(16)21/h1-12,14,22,26,28H,13H2,(H,27,29)(H,30,31)/t22-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.60	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against human gelatinase A (matrix metalloproteinase-2 MMP2)				J Med Chem 41: 640-9 (1998) Article DOI: 10.1021/jm9707582 BindingDB Entry DOI: 10.7270/Q2HD7TS9
					More data for this Ligand-Target Pair
Matrix metalloproteinase-9 (Homo sapiens (Human))	BDBM50063139 ((R)-2-[4-(4-Bromo-benzoylamino)-benzenesulfonylami...) Show SMILES OC(=O)[C@@H](Cc1c[nH]c2ccccc12)NS(=O)(=O)c1ccc(NC(=O)c2ccc(Br)cc2)cc1 Show InChI InChI=1S/C24H20BrN3O5S/c25-17-7-5-15(6-8-17)23(29)27-18-9-11-19(12-10-18)34(32,33)28-22(24(30)31)13-16-14-26-21-4-2-1-3-20(16)21/h1-12,14,22,26,28H,13H2,(H,27,29)(H,30,31)/t22-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.70	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against human gelatinase B (Matrix metalloproteinase-9)				J Med Chem 41: 640-9 (1998) Article DOI: 10.1021/jm9707582 BindingDB Entry DOI: 10.7270/Q2HD7TS9
					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50077161 ((R)-2-[5-(4-Butoxy-phenylethynyl)-thiophene-2-sulf...) Show SMILES CCCCOc1ccc(cc1)C#Cc1ccc(s1)S(=O)(=O)N[C@H](Cc1c[nH]c2ccccc12)C(O)=O Show InChI InChI=1S/C27H26N2O5S2/c1-2-3-16-34-21-11-8-19(9-12-21)10-13-22-14-15-26(35-22)36(32,33)29-25(27(30)31)17-20-18-28-24-7-5-4-6-23(20)24/h4-9,11-12,14-15,18,25,28-29H,2-3,16-17H2,1H3,(H,30,31)/t25-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.90	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Company, Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against Matrix metalloproteinase-2 (concentration required for 50% inhibition of enzyme activity)				J Med Chem 42: 1723-38 (1999) Article DOI: 10.1021/jm980514x BindingDB Entry DOI: 10.7270/Q2KP81BQ
					More data for this Ligand-Target Pair
Matrix metalloproteinase-9 (Homo sapiens (Human))	BDBM50063154 ((R)-2-{4-[2-(4-Bromo-phenyl)-2H-tetrazol-5-yl]-ben...) Show SMILES OC(=O)[C@@H](Cc1c[nH]c2ccccc12)NS(=O)(=O)c1ccc(cc1)-c1nnn(n1)-c1ccc(Br)cc1 Show InChI InChI=1S/C24H19BrN6O4S/c25-17-7-9-18(10-8-17)31-28-23(27-30-31)15-5-11-19(12-6-15)36(34,35)29-22(24(32)33)13-16-14-26-21-4-2-1-3-20(16)21/h1-12,14,22,26,29H,13H2,(H,32,33)/t22-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.10	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against human gelatinase B (Matrix metalloproteinase-9)				J Med Chem 41: 640-9 (1998) Article DOI: 10.1021/jm9707582 BindingDB Entry DOI: 10.7270/Q2HD7TS9
					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50077155 ((R)-2-[5-(4-Butyl-phenylethynyl)-thiophene-2-sulfo...) Show SMILES CCCCc1ccc(cc1)C#Cc1ccc(s1)S(=O)(=O)N[C@H](Cc1c[nH]c2ccccc12)C(O)=O Show InChI InChI=1S/C27H26N2O4S2/c1-2-3-6-19-9-11-20(12-10-19)13-14-22-15-16-26(34-22)35(32,33)29-25(27(30)31)17-21-18-28-24-8-5-4-7-23(21)24/h4-5,7-12,15-16,18,25,28-29H,2-3,6,17H2,1H3,(H,30,31)/t25-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.40	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Company, Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against Matrix metalloproteinase-2 (concentration required for 50% inhibition of enzyme activity)				J Med Chem 42: 1723-38 (1999) Article DOI: 10.1021/jm980514x BindingDB Entry DOI: 10.7270/Q2KP81BQ
					More data for this Ligand-Target Pair
Matrix metalloproteinase-9 (Homo sapiens (Human))	BDBM50077151 ((R)-2-[5-(4-Ethyl-phenylethynyl)-thiophene-2-sulfo...) Show SMILES CCc1ccc(cc1)C#Cc1ccc(s1)S(=O)(=O)N[C@H](C(C)C)C(O)=O Show InChI InChI=1S/C19H21NO4S2/c1-4-14-5-7-15(8-6-14)9-10-16-11-12-17(25-16)26(23,24)20-18(13(2)3)19(21)22/h5-8,11-13,18,20H,4H2,1-3H3,(H,21,22)/t18-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.40	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Company, Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against Matrix metalloproteinase-9 (concentration required for 50% inhibition of enzyme activity)				J Med Chem 42: 1723-38 (1999) Article DOI: 10.1021/jm980514x BindingDB Entry DOI: 10.7270/Q2KP81BQ
					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50077152 ((R)-3-Phenyl-2-([1,1';4',1'']terphenyl-4-sulfonyla...) Show SMILES OC(=O)[C@@H](Cc1ccccc1)NS(=O)(=O)c1ccc(cc1)-c1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C27H23NO4S/c29-27(30)26(19-20-7-3-1-4-8-20)28-33(31,32)25-17-15-24(16-18-25)23-13-11-22(12-14-23)21-9-5-2-6-10-21/h1-18,26,28H,19H2,(H,29,30)/t26-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.40	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Company, Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against Matrix metalloproteinase-2 (concentration required for 50% inhibition of enzyme activity)				J Med Chem 42: 1723-38 (1999) Article DOI: 10.1021/jm980514x BindingDB Entry DOI: 10.7270/Q2KP81BQ
					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50077163 ((R)-2-[5-(4-Butoxy-phenylethynyl)-thiophene-2-sulf...) Show SMILES CCCCOc1ccc(cc1)C#Cc1ccc(s1)S(=O)(=O)N[C@H](C(C)C)C(O)=O Show InChI InChI=1S/C21H25NO5S2/c1-4-5-14-27-17-9-6-16(7-10-17)8-11-18-12-13-19(28-18)29(25,26)22-20(15(2)3)21(23)24/h6-7,9-10,12-13,15,20,22H,4-5,14H2,1-3H3,(H,23,24)/t20-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.70	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Company, Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against Matrix metalloproteinase-2 (concentration required for 50% inhibition of enzyme activity)				J Med Chem 42: 1723-38 (1999) Article DOI: 10.1021/jm980514x BindingDB Entry DOI: 10.7270/Q2KP81BQ
					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50077151 ((R)-2-[5-(4-Ethyl-phenylethynyl)-thiophene-2-sulfo...) Show SMILES CCc1ccc(cc1)C#Cc1ccc(s1)S(=O)(=O)N[C@H](C(C)C)C(O)=O Show InChI InChI=1S/C19H21NO4S2/c1-4-14-5-7-15(8-6-14)9-10-16-11-12-17(25-16)26(23,24)20-18(13(2)3)19(21)22/h5-8,11-13,18,20H,4H2,1-3H3,(H,21,22)/t18-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.80	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Company, Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against Matrix metalloproteinase-2 (concentration required for 50% inhibition of enzyme activity)				J Med Chem 42: 1723-38 (1999) Article DOI: 10.1021/jm980514x BindingDB Entry DOI: 10.7270/Q2KP81BQ
					More data for this Ligand-Target Pair
Matrix metalloproteinase-9 (Homo sapiens (Human))	BDBM50063148 ((R)-2-(Biphenyl-4-sulfonylamino)-N-hydroxy-3-(1H-i...) Show SMILES ONC(=O)[C@@H](Cc1c[nH]c2ccccc12)NS(=O)(=O)c1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C23H21N3O4S/c27-23(25-28)22(14-18-15-24-21-9-5-4-8-20(18)21)26-31(29,30)19-12-10-17(11-13-19)16-6-2-1-3-7-16/h1-13,15,22,24,26,28H,14H2,(H,25,27)/t22-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against human gelatinase B (Matrix metalloproteinase-9)				J Med Chem 41: 640-9 (1998) Article DOI: 10.1021/jm9707582 BindingDB Entry DOI: 10.7270/Q2HD7TS9
					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50077158 ((R)-2-[5-(4-Butyl-phenylethynyl)-thiophene-2-sulfo...) Show SMILES CCCCc1ccc(cc1)C#Cc1ccc(s1)S(=O)(=O)N[C@H](C(C)C)C(O)=O Show InChI InChI=1S/C21H25NO4S2/c1-4-5-6-16-7-9-17(10-8-16)11-12-18-13-14-19(27-18)28(25,26)22-20(15(2)3)21(23)24/h7-10,13-15,20,22H,4-6H2,1-3H3,(H,23,24)/t20-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.40	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Company, Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against Matrix metalloproteinase-2 (concentration required for 50% inhibition of enzyme activity)				J Med Chem 42: 1723-38 (1999) Article DOI: 10.1021/jm980514x BindingDB Entry DOI: 10.7270/Q2KP81BQ
					More data for this Ligand-Target Pair
Matrix metalloproteinase-9 (Homo sapiens (Human))	BDBM50063137 ((R)-3-Methyl-2-{4-[2-(4-methylsulfanyl-phenyl)-2H-...) Show SMILES CSc1ccc(cc1)-n1nnc(n1)-c1ccc(cc1)S(=O)(=O)N[C@H](C(C)C)C(O)=O Show InChI InChI=1S/C19H21N5O4S2/c1-12(2)17(19(25)26)22-30(27,28)16-10-4-13(5-11-16)18-20-23-24(21-18)14-6-8-15(29-3)9-7-14/h4-12,17,22H,1-3H3,(H,25,26)/t17-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.90	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against human gelatinase B (Matrix metalloproteinase-9)				J Med Chem 41: 640-9 (1998) Article DOI: 10.1021/jm9707582 BindingDB Entry DOI: 10.7270/Q2HD7TS9
					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50063164 ((R)-3-Methyl-2-(5-p-tolylethynyl-thiophene-2-sulfo...) Show SMILES CC(C)[C@@H](NS(=O)(=O)c1ccc(s1)C#Cc1ccc(C)cc1)C(O)=O Show InChI InChI=1S/C18H19NO4S2/c1-12(2)17(18(20)21)19-25(22,23)16-11-10-15(24-16)9-8-14-6-4-13(3)5-7-14/h4-7,10-12,17,19H,1-3H3,(H,20,21)/t17-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.90	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Company, Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against Matrix metalloproteinase-2 (concentration required for 50% inhibition of enzyme activity)				J Med Chem 42: 1723-38 (1999) Article DOI: 10.1021/jm980514x BindingDB Entry DOI: 10.7270/Q2KP81BQ
					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50063166 ((R)-3-(1H-Indol-3-yl)-2-(4'-methoxy-biphenyl-4-sul...) Show SMILES COc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N[C@H](Cc1c[nH]c2ccccc12)C(O)=O Show InChI InChI=1S/C24H22N2O5S/c1-31-19-10-6-16(7-11-19)17-8-12-20(13-9-17)32(29,30)26-23(24(27)28)14-18-15-25-22-5-3-2-4-21(18)22/h2-13,15,23,25-26H,14H2,1H3,(H,27,28)/t23-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.5	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against human gelatinase A (matrix metalloproteinase-2 MMP2)				J Med Chem 41: 640-9 (1998) Article DOI: 10.1021/jm9707582 BindingDB Entry DOI: 10.7270/Q2HD7TS9
					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50063138 ((R)-3-Methyl-2-[4-(4-methylsulfanyl-benzoylamino)-...) Show SMILES CSc1ccc(cc1)C(=O)Nc1ccc(cc1)S(=O)(=O)N[C@H](C(C)C)C(O)=O Show InChI InChI=1S/C19H22N2O5S2/c1-12(2)17(19(23)24)21-28(25,26)16-10-6-14(7-11-16)20-18(22)13-4-8-15(27-3)9-5-13/h4-12,17,21H,1-3H3,(H,20,22)(H,23,24)/t17-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.70	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against human gelatinase A (matrix metalloproteinase-2 MMP2)				J Med Chem 41: 640-9 (1998) Article DOI: 10.1021/jm9707582 BindingDB Entry DOI: 10.7270/Q2HD7TS9
					More data for this Ligand-Target Pair
Matrix metalloproteinase-9 (Homo sapiens (Human))	BDBM50077157 ((R)-2-[5-(4-Ethyl-phenylethynyl)-thiophene-2-sulfo...) Show SMILES CCc1ccc(cc1)C#Cc1ccc(s1)S(=O)(=O)N[C@H](Cc1c[nH]c2ccccc12)C(O)=O Show InChI InChI=1S/C25H22N2O4S2/c1-2-17-7-9-18(10-8-17)11-12-20-13-14-24(32-20)33(30,31)27-23(25(28)29)15-19-16-26-22-6-4-3-5-21(19)22/h3-10,13-14,16,23,26-27H,2,15H2,1H3,(H,28,29)/t23-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.30	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Company, Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against Matrix metalloproteinase-9 (concentration required for 50% inhibition of enzyme activity)				J Med Chem 42: 1723-38 (1999) Article DOI: 10.1021/jm980514x BindingDB Entry DOI: 10.7270/Q2KP81BQ
					More data for this Ligand-Target Pair
Matrix metalloproteinase-9 (Homo sapiens (Human))	BDBM50077162 ((R)-3-(1H-Indol-3-yl)-2-[4-(4-methoxy-phenylethyny...) Show SMILES COc1ccc(cc1)C#Cc1ccc(cc1)S(=O)(=O)N[C@H](Cc1c[nH]c2ccccc12)C(O)=O Show InChI InChI=1S/C26H22N2O5S/c1-33-21-12-8-18(9-13-21)6-7-19-10-14-22(15-11-19)34(31,32)28-25(26(29)30)16-20-17-27-24-5-3-2-4-23(20)24/h2-5,8-15,17,25,27-28H,16H2,1H3,(H,29,30)/t25-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	8.20	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Company, Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against Matrix metalloproteinase-9 (concentration required for 50% inhibition of enzyme activity)				J Med Chem 42: 1723-38 (1999) Article DOI: 10.1021/jm980514x BindingDB Entry DOI: 10.7270/Q2KP81BQ
					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50063154 ((R)-2-{4-[2-(4-Bromo-phenyl)-2H-tetrazol-5-yl]-ben...) Show SMILES OC(=O)[C@@H](Cc1c[nH]c2ccccc12)NS(=O)(=O)c1ccc(cc1)-c1nnn(n1)-c1ccc(Br)cc1 Show InChI InChI=1S/C24H19BrN6O4S/c25-17-7-9-18(10-8-17)31-28-23(27-30-31)15-5-11-19(12-6-15)36(34,35)29-22(24(32)33)13-16-14-26-21-4-2-1-3-20(16)21/h1-12,14,22,26,29H,13H2,(H,32,33)/t22-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.30	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against human gelatinase A (matrix metalloproteinase-2 MMP2)				J Med Chem 41: 640-9 (1998) Article DOI: 10.1021/jm9707582 BindingDB Entry DOI: 10.7270/Q2HD7TS9
					More data for this Ligand-Target Pair
Matrix metalloproteinase-9 (Homo sapiens (Human))	BDBM50063129 ((R)-3-(1H-Indol-3-yl)-2-(5-p-tolylethynyl-thiophen...) Show SMILES Cc1ccc(cc1)C#Cc1ccc(s1)S(=O)(=O)N[C@H](Cc1c[nH]c2ccccc12)C(O)=O Show InChI InChI=1S/C24H20N2O4S2/c1-16-6-8-17(9-7-16)10-11-19-12-13-23(31-19)32(29,30)26-22(24(27)28)14-18-15-25-21-5-3-2-4-20(18)21/h2-9,12-13,15,22,25-26H,14H2,1H3,(H,27,28)/t22-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	9.60	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Company, Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against Matrix metalloproteinase-9 (concentration required for 50% inhibition of enzyme activity)				J Med Chem 42: 1723-38 (1999) Article DOI: 10.1021/jm980514x BindingDB Entry DOI: 10.7270/Q2KP81BQ
					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50063147 ((R)-2-[5-(4-Methoxy-phenylethynyl)-thiophene-2-sul...) Show SMILES COc1ccc(cc1)C#Cc1ccc(s1)S(=O)(=O)N[C@H](Cc1ccccc1)C(O)=O Show InChI InChI=1S/C22H19NO5S2/c1-28-18-10-7-16(8-11-18)9-12-19-13-14-21(29-19)30(26,27)23-20(22(24)25)15-17-5-3-2-4-6-17/h2-8,10-11,13-14,20,23H,15H2,1H3,(H,24,25)/t20-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against human gelatinase A (matrix metalloproteinase-2 MMP2)				J Med Chem 41: 640-9 (1998) Article DOI: 10.1021/jm9707582 BindingDB Entry DOI: 10.7270/Q2HD7TS9
					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50077164 ((R)-3-(1H-Indol-3-yl)-2-[5-(4-phenoxy-phenylethyny...) Show SMILES OC(=O)[C@@H](Cc1c[nH]c2ccccc12)NS(=O)(=O)c1ccc(s1)C#Cc1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C29H22N2O5S2/c32-29(33)27(18-21-19-30-26-9-5-4-8-25(21)26)31-38(34,35)28-17-16-24(37-28)15-12-20-10-13-23(14-11-20)36-22-6-2-1-3-7-22/h1-11,13-14,16-17,19,27,30-31H,18H2,(H,32,33)/t27-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Company, Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against Matrix metalloproteinase-2 (concentration required for 50% inhibition of enzyme activity)				J Med Chem 42: 1723-38 (1999) Article DOI: 10.1021/jm980514x BindingDB Entry DOI: 10.7270/Q2KP81BQ
					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50063151 ((R)-3-(1H-Indol-3-yl)-2-(5-p-tolyl-thiophene-2-sul...) Show SMILES Cc1ccc(cc1)-c1ccc(s1)S(=O)(=O)N[C@H](Cc1c[nH]c2ccccc12)C(O)=O Show InChI InChI=1S/C22H20N2O4S2/c1-14-6-8-15(9-7-14)20-10-11-21(29-20)30(27,28)24-19(22(25)26)12-16-13-23-18-5-3-2-4-17(16)18/h2-11,13,19,23-24H,12H2,1H3,(H,25,26)/t19-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against human gelatinase A (matrix metalloproteinase-2 MMP2)				J Med Chem 41: 640-9 (1998) Article DOI: 10.1021/jm9707582 BindingDB Entry DOI: 10.7270/Q2HD7TS9
					More data for this Ligand-Target Pair
Matrix metalloproteinase-9 (Homo sapiens (Human))	BDBM50077152 ((R)-3-Phenyl-2-([1,1';4',1'']terphenyl-4-sulfonyla...) Show SMILES OC(=O)[C@@H](Cc1ccccc1)NS(=O)(=O)c1ccc(cc1)-c1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C27H23NO4S/c29-27(30)26(19-20-7-3-1-4-8-20)28-33(31,32)25-17-15-24(16-18-25)23-13-11-22(12-14-23)21-9-5-2-6-10-21/h1-18,26,28H,19H2,(H,29,30)/t26-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Company, Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against Matrix metalloproteinase-9 (concentration required for 50% inhibition of enzyme activity)				J Med Chem 42: 1723-38 (1999) Article DOI: 10.1021/jm980514x BindingDB Entry DOI: 10.7270/Q2KP81BQ
					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50063137 ((R)-3-Methyl-2-{4-[2-(4-methylsulfanyl-phenyl)-2H-...) Show SMILES CSc1ccc(cc1)-n1nnc(n1)-c1ccc(cc1)S(=O)(=O)N[C@H](C(C)C)C(O)=O Show InChI InChI=1S/C19H21N5O4S2/c1-12(2)17(19(25)26)22-30(27,28)16-10-4-13(5-11-16)18-20-23-24(21-18)14-6-8-15(29-3)9-7-14/h4-12,17,22H,1-3H3,(H,25,26)/t17-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against human gelatinase A (matrix metalloproteinase-2 MMP2)				J Med Chem 41: 640-9 (1998) Article DOI: 10.1021/jm9707582 BindingDB Entry DOI: 10.7270/Q2HD7TS9
					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50063156 ((R)-3-(1H-Indol-3-yl)-2-{4-[2-(4-methoxy-phenyl)-2...) Show SMILES COc1ccc(cc1)-n1nnc(n1)-c1ccc(cc1)S(=O)(=O)N[C@H](Cc1c[nH]c2ccccc12)C(O)=O Show InChI InChI=1S/C25H22N6O5S/c1-36-19-10-8-18(9-11-19)31-28-24(27-30-31)16-6-12-20(13-7-16)37(34,35)29-23(25(32)33)14-17-15-26-22-5-3-2-4-21(17)22/h2-13,15,23,26,29H,14H2,1H3,(H,32,33)/t23-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against human gelatinase A (matrix metalloproteinase-2 MMP2)				J Med Chem 41: 640-9 (1998) Article DOI: 10.1021/jm9707582 BindingDB Entry DOI: 10.7270/Q2HD7TS9
					More data for this Ligand-Target Pair
Matrix metalloproteinase-9 (Homo sapiens (Human))	BDBM50063164 ((R)-3-Methyl-2-(5-p-tolylethynyl-thiophene-2-sulfo...) Show SMILES CC(C)[C@@H](NS(=O)(=O)c1ccc(s1)C#Cc1ccc(C)cc1)C(O)=O Show InChI InChI=1S/C18H19NO4S2/c1-12(2)17(18(20)21)19-25(22,23)16-11-10-15(24-16)9-8-14-6-4-13(3)5-7-14/h4-7,10-12,17,19H,1-3H3,(H,20,21)/t17-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against human gelatinase B (Matrix metalloproteinase-9)				J Med Chem 41: 640-9 (1998) Article DOI: 10.1021/jm9707582 BindingDB Entry DOI: 10.7270/Q2HD7TS9
					More data for this Ligand-Target Pair
Matrix metalloproteinase-9 (Homo sapiens (Human))	BDBM50063138 ((R)-3-Methyl-2-[4-(4-methylsulfanyl-benzoylamino)-...) Show SMILES CSc1ccc(cc1)C(=O)Nc1ccc(cc1)S(=O)(=O)N[C@H](C(C)C)C(O)=O Show InChI InChI=1S/C19H22N2O5S2/c1-12(2)17(19(23)24)21-28(25,26)16-10-6-14(7-11-16)20-18(22)13-4-8-15(27-3)9-5-13/h4-12,17,21H,1-3H3,(H,20,22)(H,23,24)/t17-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against human gelatinase B (Matrix metalloproteinase-9)				J Med Chem 41: 640-9 (1998) Article DOI: 10.1021/jm9707582 BindingDB Entry DOI: 10.7270/Q2HD7TS9
					More data for this Ligand-Target Pair
Matrix metalloproteinase-9 (Homo sapiens (Human))	BDBM50063174 ((R)-3-(1H-Indol-3-yl)-2-(4-p-tolylethynyl-benzenes...) Show SMILES Cc1ccc(cc1)C#Cc1ccc(cc1)S(=O)(=O)N[C@H](Cc1c[nH]c2ccccc12)C(O)=O Show InChI InChI=1S/C26H22N2O4S/c1-18-6-8-19(9-7-18)10-11-20-12-14-22(15-13-20)33(31,32)28-25(26(29)30)16-21-17-27-24-5-3-2-4-23(21)24/h2-9,12-15,17,25,27-28H,16H2,1H3,(H,29,30)/t25-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against human gelatinase B (Matrix metalloproteinase-9)				J Med Chem 41: 640-9 (1998) Article DOI: 10.1021/jm9707582 BindingDB Entry DOI: 10.7270/Q2HD7TS9
					More data for this Ligand-Target Pair
Matrix metalloproteinase-9 (Homo sapiens (Human))	BDBM50063156 ((R)-3-(1H-Indol-3-yl)-2-{4-[2-(4-methoxy-phenyl)-2...) Show SMILES COc1ccc(cc1)-n1nnc(n1)-c1ccc(cc1)S(=O)(=O)N[C@H](Cc1c[nH]c2ccccc12)C(O)=O Show InChI InChI=1S/C25H22N6O5S/c1-36-19-10-8-18(9-11-19)31-28-24(27-30-31)16-6-12-20(13-7-16)37(34,35)29-23(25(32)33)14-17-15-26-22-5-3-2-4-21(17)22/h2-13,15,23,26,29H,14H2,1H3,(H,32,33)/t23-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against human gelatinase B (Matrix metalloproteinase-9)				J Med Chem 41: 640-9 (1998) Article DOI: 10.1021/jm9707582 BindingDB Entry DOI: 10.7270/Q2HD7TS9
					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50063140 ((2R)-[(4-biphenylylsulfonyl) amino]-N-hydroxy-3-ph...) Show SMILES ONC(=O)[C@@H](Cc1ccccc1)NS(=O)(=O)c1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C21H20N2O4S/c24-21(22-25)20(15-16-7-3-1-4-8-16)23-28(26,27)19-13-11-18(12-14-19)17-9-5-2-6-10-17/h1-14,20,23,25H,15H2,(H,22,24)/t20-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against human gelatinase A (matrix metalloproteinase-2 MMP2)				J Med Chem 41: 640-9 (1998) Article DOI: 10.1021/jm9707582 BindingDB Entry DOI: 10.7270/Q2HD7TS9
					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50077149 ((R)-3-Methyl-2-[5-(4-phenoxy-phenylethynyl)-thioph...) Show SMILES CC(C)[C@@H](NS(=O)(=O)c1ccc(s1)C#Cc1ccc(Oc2ccccc2)cc1)C(O)=O Show InChI InChI=1S/C23H21NO5S2/c1-16(2)22(23(25)26)24-31(27,28)21-15-14-20(30-21)13-10-17-8-11-19(12-9-17)29-18-6-4-3-5-7-18/h3-9,11-12,14-16,22,24H,1-2H3,(H,25,26)/t22-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Company, Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against Matrix metalloproteinase-2 (concentration required for 50% inhibition of enzyme activity)				J Med Chem 42: 1723-38 (1999) Article DOI: 10.1021/jm980514x BindingDB Entry DOI: 10.7270/Q2KP81BQ
					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50063150 ((R)-3-(1H-Indol-3-yl)-2-[4-(2-phenyl-2H-tetrazol-5...) Show SMILES OC(=O)[C@@H](Cc1c[nH]c2ccccc12)NS(=O)(=O)c1ccc(cc1)-c1nnn(n1)-c1ccccc1 Show InChI InChI=1S/C24H20N6O4S/c31-24(32)22(14-17-15-25-21-9-5-4-8-20(17)21)28-35(33,34)19-12-10-16(11-13-19)23-26-29-30(27-23)18-6-2-1-3-7-18/h1-13,15,22,25,28H,14H2,(H,31,32)/t22-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against human gelatinase A (matrix metalloproteinase-2 MMP2)				J Med Chem 41: 640-9 (1998) Article DOI: 10.1021/jm9707582 BindingDB Entry DOI: 10.7270/Q2HD7TS9
					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50077153 ((R)-3-Phenyl-2-(4-phenylethynyl-benzenesulfonylami...) Show SMILES OC(=O)[C@@H](Cc1ccccc1)NS(=O)(=O)c1ccc(cc1)C#Cc1ccccc1 Show InChI InChI=1S/C23H19NO4S/c25-23(26)22(17-20-9-5-2-6-10-20)24-29(27,28)21-15-13-19(14-16-21)12-11-18-7-3-1-4-8-18/h1-10,13-16,22,24H,17H2,(H,25,26)/t22-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Company, Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against Matrix metalloproteinase-2 (concentration required for 50% inhibition of enzyme activity)				J Med Chem 42: 1723-38 (1999) Article DOI: 10.1021/jm980514x BindingDB Entry DOI: 10.7270/Q2KP81BQ
					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50063129 ((R)-3-(1H-Indol-3-yl)-2-(5-p-tolylethynyl-thiophen...) Show SMILES Cc1ccc(cc1)C#Cc1ccc(s1)S(=O)(=O)N[C@H](Cc1c[nH]c2ccccc12)C(O)=O Show InChI InChI=1S/C24H20N2O4S2/c1-16-6-8-17(9-7-16)10-11-19-12-13-23(31-19)32(29,30)26-22(24(27)28)14-18-15-25-21-5-3-2-4-20(18)21/h2-9,12-13,15,22,25-26H,14H2,1H3,(H,27,28)/t22-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against human gelatinase A (matrix metalloproteinase-2 MMP2)				J Med Chem 41: 640-9 (1998) Article DOI: 10.1021/jm9707582 BindingDB Entry DOI: 10.7270/Q2HD7TS9
					More data for this Ligand-Target Pair
Matrix metalloproteinase-9 (Homo sapiens (Human))	BDBM50063129 ((R)-3-(1H-Indol-3-yl)-2-(5-p-tolylethynyl-thiophen...) Show SMILES Cc1ccc(cc1)C#Cc1ccc(s1)S(=O)(=O)N[C@H](Cc1c[nH]c2ccccc12)C(O)=O Show InChI InChI=1S/C24H20N2O4S2/c1-16-6-8-17(9-7-16)10-11-19-12-13-23(31-19)32(29,30)26-22(24(27)28)14-18-15-25-21-5-3-2-4-20(18)21/h2-9,12-13,15,22,25-26H,14H2,1H3,(H,27,28)/t22-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against human gelatinase B (Matrix metalloproteinase-9)				J Med Chem 41: 640-9 (1998) Article DOI: 10.1021/jm9707582 BindingDB Entry DOI: 10.7270/Q2HD7TS9
					More data for this Ligand-Target Pair
Matrix metalloproteinase-9 (Homo sapiens (Human))	BDBM50063153 ((R)-3-(1H-Indol-3-yl)-2-[5-(4-nitro-phenylethynyl)...) Show SMILES OC(=O)[C@@H](Cc1c[nH]c2ccccc12)NS(=O)(=O)c1ccc(s1)C#Cc1ccc(cc1)[N+]([O-])=O Show InChI InChI=1S/C23H17N3O6S2/c27-23(28)21(13-16-14-24-20-4-2-1-3-19(16)20)25-34(31,32)22-12-11-18(33-22)10-7-15-5-8-17(9-6-15)26(29)30/h1-6,8-9,11-12,14,21,24-25H,13H2,(H,27,28)/t21-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against human gelatinase B (Matrix metalloproteinase-9)				J Med Chem 41: 640-9 (1998) Article DOI: 10.1021/jm9707582 BindingDB Entry DOI: 10.7270/Q2HD7TS9
					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50063132 ((R)-3-Methyl-2-(4'-methylsulfanyl-biphenyl-4-sulfo...) Show SMILES CSc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N[C@H](C(C)C)C(O)=O Show InChI InChI=1S/C18H21NO4S2/c1-12(2)17(18(20)21)19-25(22,23)16-10-6-14(7-11-16)13-4-8-15(24-3)9-5-13/h4-12,17,19H,1-3H3,(H,20,21)/t17-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against human gelatinase A (matrix metalloproteinase-2 MMP2)				J Med Chem 41: 640-9 (1998) Article DOI: 10.1021/jm9707582 BindingDB Entry DOI: 10.7270/Q2HD7TS9
					More data for this Ligand-Target Pair
Matrix metalloproteinase-9 (Homo sapiens (Human))	BDBM50063147 ((R)-2-[5-(4-Methoxy-phenylethynyl)-thiophene-2-sul...) Show SMILES COc1ccc(cc1)C#Cc1ccc(s1)S(=O)(=O)N[C@H](Cc1ccccc1)C(O)=O Show InChI InChI=1S/C22H19NO5S2/c1-28-18-10-7-16(8-11-18)9-12-19-13-14-21(29-19)30(26,27)23-20(22(24)25)15-17-5-3-2-4-6-17/h2-8,10-11,13-14,20,23H,15H2,1H3,(H,24,25)/t20-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against human gelatinase B (Matrix metalloproteinase-9)				J Med Chem 41: 640-9 (1998) Article DOI: 10.1021/jm9707582 BindingDB Entry DOI: 10.7270/Q2HD7TS9
					More data for this Ligand-Target Pair
Matrix metalloproteinase-9 (Homo sapiens (Human))	BDBM50063164 ((R)-3-Methyl-2-(5-p-tolylethynyl-thiophene-2-sulfo...) Show SMILES CC(C)[C@@H](NS(=O)(=O)c1ccc(s1)C#Cc1ccc(C)cc1)C(O)=O Show InChI InChI=1S/C18H19NO4S2/c1-12(2)17(18(20)21)19-25(22,23)16-11-10-15(24-16)9-8-14-6-4-13(3)5-7-14/h4-7,10-12,17,19H,1-3H3,(H,20,21)/t17-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Company, Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against Matrix metalloproteinase-9 (concentration required for 50% inhibition of enzyme activity)				J Med Chem 42: 1723-38 (1999) Article DOI: 10.1021/jm980514x BindingDB Entry DOI: 10.7270/Q2KP81BQ
					More data for this Ligand-Target Pair
Matrix metalloproteinase-9 (Homo sapiens (Human))	BDBM50063140 ((2R)-[(4-biphenylylsulfonyl) amino]-N-hydroxy-3-ph...) Show SMILES ONC(=O)[C@@H](Cc1ccccc1)NS(=O)(=O)c1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C21H20N2O4S/c24-21(22-25)20(15-16-7-3-1-4-8-16)23-28(26,27)19-13-11-18(12-14-19)17-9-5-2-6-10-17/h1-14,20,23,25H,15H2,(H,22,24)/t20-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against human gelatinase B (Matrix metalloproteinase-9)				J Med Chem 41: 640-9 (1998) Article DOI: 10.1021/jm9707582 BindingDB Entry DOI: 10.7270/Q2HD7TS9
					More data for this Ligand-Target Pair
Matrix metalloproteinase-9 (Homo sapiens (Human))	BDBM50063150 ((R)-3-(1H-Indol-3-yl)-2-[4-(2-phenyl-2H-tetrazol-5...) Show SMILES OC(=O)[C@@H](Cc1c[nH]c2ccccc12)NS(=O)(=O)c1ccc(cc1)-c1nnn(n1)-c1ccccc1 Show InChI InChI=1S/C24H20N6O4S/c31-24(32)22(14-17-15-25-21-9-5-4-8-20(17)21)28-35(33,34)19-12-10-16(11-13-19)23-26-29-30(27-23)18-6-2-1-3-7-18/h1-13,15,22,25,28H,14H2,(H,31,32)/t22-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against human gelatinase B (Matrix metalloproteinase-9)				J Med Chem 41: 640-9 (1998) Article DOI: 10.1021/jm9707582 BindingDB Entry DOI: 10.7270/Q2HD7TS9
					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50077150 ((R)-3-(1H-Indol-3-yl)-2-[4-(4-methoxy-phenylethyny...) Show SMILES COc1ccc(cc1)C#Cc1ccc(cc1[N+]([O-])=O)S(=O)(=O)N[C@H](Cc1c[nH]c2ccccc12)C(O)=O Show InChI InChI=1S/C26H21N3O7S/c1-36-20-11-7-17(8-12-20)6-9-18-10-13-21(15-25(18)29(32)33)37(34,35)28-24(26(30)31)14-19-16-27-23-5-3-2-4-22(19)23/h2-5,7-8,10-13,15-16,24,27-28H,14H2,1H3,(H,30,31)/t24-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Company, Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against Matrix metalloproteinase-2 (concentration required for 50% inhibition of enzyme activity)				J Med Chem 42: 1723-38 (1999) Article DOI: 10.1021/jm980514x BindingDB Entry DOI: 10.7270/Q2KP81BQ
					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50063174 ((R)-3-(1H-Indol-3-yl)-2-(4-p-tolylethynyl-benzenes...) Show SMILES Cc1ccc(cc1)C#Cc1ccc(cc1)S(=O)(=O)N[C@H](Cc1c[nH]c2ccccc12)C(O)=O Show InChI InChI=1S/C26H22N2O4S/c1-18-6-8-19(9-7-18)10-11-20-12-14-22(15-13-20)33(31,32)28-25(26(29)30)16-21-17-27-24-5-3-2-4-23(21)24/h2-9,12-15,17,25,27-28H,16H2,1H3,(H,29,30)/t25-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	34	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against human gelatinase A (matrix metalloproteinase-2 MMP2)				J Med Chem 41: 640-9 (1998) Article DOI: 10.1021/jm9707582 BindingDB Entry DOI: 10.7270/Q2HD7TS9
					More data for this Ligand-Target Pair
Matrix metalloproteinase-9 (Homo sapiens (Human))	BDBM50063132 ((R)-3-Methyl-2-(4'-methylsulfanyl-biphenyl-4-sulfo...) Show SMILES CSc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N[C@H](C(C)C)C(O)=O Show InChI InChI=1S/C18H21NO4S2/c1-12(2)17(18(20)21)19-25(22,23)16-10-6-14(7-11-16)13-4-8-15(24-3)9-5-13/h4-12,17,19H,1-3H3,(H,20,21)/t17-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against human gelatinase B (Matrix metalloproteinase-9)				J Med Chem 41: 640-9 (1998) Article DOI: 10.1021/jm9707582 BindingDB Entry DOI: 10.7270/Q2HD7TS9
					More data for this Ligand-Target Pair

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