| Reaction Details |
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 | Report a problem with these data |
| Target | Protein arginine N-methyltransferase 1 |
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| Ligand | BDBM50511922 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1846162 (CHEMBL4346589) |
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| IC50 | 15000±n/a nM |
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| Citation |  Shen, Y; Li, F; Szewczyk, MM; Halabelian, L; Park, KS; Chau, I; Dong, A; Zeng, H; Chen, H; Meng, F; Barsyte-Lovejoy, D; Arrowsmith, CH; Brown, PJ; Liu, J; Vedadi, M; Jin, J Discovery of a First-in-Class Protein Arginine Methyltransferase 6 (PRMT6) Covalent Inhibitor. J Med Chem63:5477-5487 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein arginine N-methyltransferase 1 |
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| Name: | Protein arginine N-methyltransferase 1 |
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| Synonyms: | 2.1.1.319 | ANM1_HUMAN | HMT2 | HRMT1L2 | HRMT1L2 {ECO:0000303|PubMed:11097842 | Histone-arginine N-methyltransferase PRMT1 | IR1B4 | Interferon receptor 1-bound protein 4 | PRMT1 | Protein arginine N-methyltransferase 1 | Protein-arginine N-methyltransferase 1 | Synonyms=HMT2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 42451.61 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_100878 |
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| Residue: | 371 |
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| Sequence: | MAAAEAANCIMENFVATLANGMSLQPPLEEVSCGQAESSEKPNAEDMTSKDYYFDSYAHF
GIHEEMLKDEVRTLTYRNSMFHNRHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIECS
SISDYAVKIVKANKLDHVVTIIKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVLYA
RDKWLAPDGLIFPDRATLYVTAIEDRQYKDYKIHWWENVYGFDMSCIKDVAIKEPLVDVV
DPKQLVTNACLIKEVDIYTVKVEDLTFTSPFCLQVKRNDYVHALVAYFNIEFTRCHKRTG
FSTSPESPYTHWKQTVFYMEDYLTVKTGEEIFGTIGMRPNAKNNRDLDFTIDLDFKGQLC
ELSCSTDYRMR
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| BDBM50511922 |
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| n/a |
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| Name | BDBM50511922 |
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| Synonyms: | CHEMBL4539314 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H21N3O2 |
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| Mol. Mass. | 299.3675 |
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| SMILES | CN(CCO)Cc1c[nH]cc1-c1cccc(NC(=O)C=C)c1 |
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| Structure | 
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