Reaction Details |
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Target | Nuclear factor erythroid 2-related factor 2 |
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Ligand | BDBM50521640 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1884971 (CHEMBL4386553) |
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EC50 | 3400±n/a nM |
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Citation | Heightman, TD; Callahan, JF; Chiarparin, E; Coyle, JE; Griffiths-Jones, C; Lakdawala, AS; McMenamin, R; Mortenson, PN; Norton, D; Peakman, TM; Rich, SJ; Richardson, C; Rumsey, WL; Sanchez, Y; Saxty, G; Willems, HMG; Wolfe, L; Woolford, AJ; Wu, Z; Yan, H; Kerns, JK; Davies, TG Structure-Activity and Structure-Conformation Relationships of Aryl Propionic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1/Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1/NRF2) Protein-Protein Interaction. J Med Chem62:4683-4702 (2019) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Nuclear factor erythroid 2-related factor 2 |
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Name: | Nuclear factor erythroid 2-related factor 2 |
Synonyms: | HEBP1 | Kelch-like ECH-associated protein 1 | NF-E2-related factor 2 | NF2L2_HUMAN | NFE2-related factor 2 | NFE2L2 | NRF2 | Nuclear factor erythroid 2-related factor 2 | Nuclear factor, erythroid derived 2, like 2 |
Type: | PROTEIN |
Mol. Mass.: | 67786.89 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_107924 |
Residue: | 605 |
Sequence: | MMDLELPPPGLPSQQDMDLIDILWRQDIDLGVSREVFDFSQRRKEYELEKQKKLEKERQE
QLQKEQEKAFFAQLQLDEETGEFLPIQPAQHIQSETSGSANYSQVAHIPKSDALYFDDCM
QLLAQTFPFVDDNEVSSATFQSLVPDIPGHIESPVFIATNQAQSPETSVAQVAPVDLDGM
QQDIEQVWEELLSIPELQCLNIENDKLVETTMVPSPEAKLTEVDNYHFYSSIPSMEKEVG
NCSPHFLNAFEDSFSSILSTEDPNQLTVNSLNSDATVNTDFGDEFYSAFIAEPSISNSMP
SPATLSHSLSELLNGPIDVSDLSLCKAFNQNHPESTAEFNDSDSGISLNTSPSVASPEHS
VESSSYGDTLLGLSDSEVEELDSAPGSVKQNGPKTPVHSSGDMVQPLSPSQGQSTHVHDA
QCENTPEKELPVSPGHRKTPFTKDKHSSRLEAHLTRDELRAKALHIPFPVEKIINLPVVD
FNEMMSKEQFNEAQLALIRDIRRRGKNKVAAQNCRKRKLENIVELEQDLDHLKDEKEKLL
KEKGENDKSLHLLKKQLSTLYLEVFSMLRDEDGKPYSPSEYSLQQTRDGNVFLVPKSKKP
DVKKN
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BDBM50521640 |
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n/a |
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Name | BDBM50521640 |
Synonyms: | CHEMBL4473977 |
Type | Small organic molecule |
Emp. Form. | C25H26N4O4S |
Mol. Mass. | 478.563 |
SMILES | CN(Cc1cc(ccc1C)C(CC(O)=O)c1ccc2n(C)nnc2c1)S(=O)(=O)c1ccccc1 |
Structure |
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