| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Polyamine deacetylase HDAC10 |
|---|
| Ligand | BDBM50527619 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1902914 (CHEMBL4405136) |
|---|
| IC50 | 1502±n/a nM |
|---|
| Citation |  Thakur, A; Tawa, GJ; Henderson, MJ; Danchik, C; Liu, S; Shah, P; Wang, AQ; Dunn, G; Kabir, M; Padilha, EC; Xu, X; Simeonov, A; Kharbanda, S; Stone, R; Grewal, G Design, Synthesis, and Biological Evaluation of Quinazolin-4-one-Based Hydroxamic Acids as Dual PI3K/HDAC Inhibitors. J Med Chem63:4256-4292 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Polyamine deacetylase HDAC10 |
|---|
| Name: | Polyamine deacetylase HDAC10 |
|---|
| Synonyms: | HD10 | HDA10_HUMAN | HDAC10 | Histone deacetylase | Histone deacetylase 10 | Human HDAC10 |
|---|
| Type: | Chromatin regulator; hydrolase; repressor |
|---|
| Mol. Mass.: | 71431.89 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q969S8 |
|---|
| Residue: | 669 |
|---|
| Sequence: | MGTALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEEL
GLVHSPEYVSLVRETQVLGKEELQALSGQFDAIYFHPSTFHCARLAAGAGLQLVDAVLTG
AVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQ
YLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFTVNLPWNQVGMGNADYVA
AFLHLLLPLAFEFDPELVLVSAGFDSAIGDPEGQMQATPECFAHLTQLLQVLAGGRVCAV
LEGGYHLESLAESVCMTVQTLLGDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQ
DVTAVPMSPSSHSPEGRPPPLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPD
ITLVLPPDVIQQEASALREETEAWARPHESLAREEALTALGKLLYLLDGMLDGQVNSGIA
ATPASAAAATLDVAVRRGLSHGAQRLLCVALGQLDRPPDLAHDGRSLWLNIRGKEAAALS
MFHVSTPLPVMTGGFLSCILGLVLPLAYGFQPDLVLVALGPGHGLQGPHAALLAAMLRGL
AGGRVLALLEENSTPQLAGILARVLNGEAPPSLGPSSVASPEDVQALMYLRGQLEPQWKM
LQCHPHLVA
|
|
|
|---|
| BDBM50527619 |
|---|
| n/a |
|---|
| Name | BDBM50527619 |
|---|
| Synonyms: | CHEMBL4451623 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H30N8O3 |
|---|
| Mol. Mass. | 526.5896 |
|---|
| SMILES | CC[C@H](Nc1ncnc2[nH]cnc12)c1nc2cccc(CCCCCC(=O)NO)c2c(=O)n1-c1ccccc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
