| Reaction Details |
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 | Report a problem with these data |
| Target | Bone morphogenetic protein receptor type-1B |
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| Ligand | BDBM50528194 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1992456 (CHEMBL4626191) |
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| IC50 | 68±n/a nM |
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| Citation |  Smil, D; Wong, JF; Williams, EP; Adamson, RJ; Howarth, A; McLeod, DA; Mamai, A; Kim, S; Wilson, BJ; Kiyota, T; Aman, A; Owen, J; Poda, G; Horiuchi, KY; Kuznetsova, E; Ma, H; Hamblin, JN; Cramp, S; Roberts, OG; Edwards, AM; Uehling, D; Al-Awar, R; Bullock, AN; O'Meara, JA; Isaac, MB Leveraging an Open Science Drug Discovery Model to Develop CNS-Penetrant ALK2 Inhibitors for the Treatment of Diffuse Intrinsic Pontine Glioma. J Med Chem63:10061-10085 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Bone morphogenetic protein receptor type-1B |
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| Name: | Bone morphogenetic protein receptor type-1B |
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| Synonyms: | ALK-6 | ALK6 | BMPR1B | BMR1B_HUMAN | Bone morphogenetic protein receptor type-1B (BMPR1B) |
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| Type: | Enzyme |
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| Mol. Mass.: | 56939.41 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O00238 |
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| Residue: | 502 |
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| Sequence: | MLLRSAGKLNVGTKKEDGESTAPTPRPKVLRCKCHHHCPEDSVNNICSTDGYCFTMIEED
DSGLPVVTSGCLGLEGSDFQCRDTPIPHQRRSIECCTERNECNKDLHPTLPPLKNRDFVD
GPIHHRALLISVTVCSLLLVLIILFCYFRYKRQETRPRYSIGLEQDETYIPPGESLRDLI
EQSQSSGSGSGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEAS
WFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKS
MLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISD
TNEVDIPPNTRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIV
EEYQLPYHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPAS
RLTALRVKKTLAKMSESQDIKL
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| BDBM50528194 |
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| n/a |
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| Name | BDBM50528194 |
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| Synonyms: | CHEMBL4517408 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H29N3O3 |
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| Mol. Mass. | 419.5161 |
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| SMILES | COc1cc(cc(OC)c1OC)-c1cncc(c1C)-c1ccc(cc1)N1CCNCC1 |
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| Structure | 
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