Reaction Details |
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Target | Kappa-type opioid receptor |
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Ligand | BDBM50545667 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1996168 (CHEMBL4630063) |
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Ki | 12±n/a nM |
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Citation | Vekariya, RH; Lei, W; Ray, A; Saini, SK; Zhang, S; Molnar, G; Barlow, D; Karlage, KL; Bilsky, EJ; Houseknecht, KL; Largent-Milnes, TM; Streicher, JM; Ananthan, S Synthesis and Structure-Activity Relationships of 5'-Aryl-14-alkoxypyridomorphinans: Identification of a ? Opioid Receptor Agonist/? Opioid Receptor Antagonist Ligand with Systemic Antinociceptive Activity and Diminished Opioid Side Effects. J Med Chem63:7663-7694 (2020) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Kappa-type opioid receptor |
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Name: | Kappa-type opioid receptor |
Synonyms: | K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR) |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 42648.76 |
Organism: | Homo sapiens (Human) |
Description: | P41145 |
Residue: | 380 |
Sequence: | MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPV
IITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYL
MNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINI
CIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVL
IIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALG
STSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRV
RNTVQDPAYLRDIDGMNKPV
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BDBM50545667 |
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n/a |
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Name | BDBM50545667 |
Synonyms: | CHEMBL4634021 |
Type | Small organic molecule |
Emp. Form. | C40H43N3O3 |
Mol. Mass. | 613.7877 |
SMILES | [H][C@@]12Oc3c4c(C[C@@]5([H])N(CC6CC6)CC[C@@]14[C@]5(Cc1cc(cnc21)-c1cccc(c1)N(C)C)OCCCc1ccccc1)ccc3O |r,THB:10:9:17:4.5.6| |
Structure |
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