| Reaction Details |
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 | Report a problem with these data |
| Target | Guanylate cyclase soluble subunit alpha-1/beta-1 |
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| Ligand | BDBM50547431 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2018158 (CHEMBL4671736) |
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| EC50 | 546000±n/a nM |
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| Citation |  Brockunier, L; Stelmach, J; Guo, J; Spencer, T; Rosauer, K; Bansal, A; Cai, SJ; Chen, N; Cummings, J; Huang, L; Johnson, T; Levesque, S; Luo, L; Maloney, K; Metzger, J; Mortko, C; Ortega, K; Pai, LY; Pereira, A; Salituro, G; Shang, J; Shepherd, C; Sherrie Xu, S; Yang, Q; Cui, J; Roy, S; Parmee, E; Raghavan, S Soluble guanylate cyclase stimulators for the treatment of hypertension: Discovery of MK-2947. Bioorg Med Chem Lett30:0 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Guanylate cyclase soluble subunit alpha-1/beta-1 |
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| Name: | Guanylate cyclase soluble subunit alpha-1/beta-1 |
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| Synonyms: | Soluble Guanylate Cyclases | Soluble guanylate cyclase (sGC) | Soluble guanylate cyclase alpha 1 and beta 1 subunits (sGC) | Soluble guanylate cyclase alpha1/beta1 complex | soluble guanylate cyclase activators | soluble guanylate cyclase apha 1 and soluble guanylate cyclase beta 1 |
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| Type: | Enzyme |
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| Mol. Mass.: | n/a |
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| Description: | n/a |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Guanylate cyclase soluble subunit alpha-1 |
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| Synonyms: | GCS-alpha-1 | GCS-alpha-3 | GCYA1_HUMAN | GUC1A3 | GUCSA3 | GUCY1A1 | GUCY1A3 | Guanylate cyclase soluble (GCS-alpha-1) | Guanylate cyclase soluble subunit alpha-3 | Solube guanylate cyclase alpha-1 (sGC alpha-1) | Solube guanylate cyclase alpha-1 (sGCalpha) | soluble guanylate cyclase alpha-1 (sGC) |
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| Type: | Enzyme |
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| Mol. Mass.: | 77457.21 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q02108 |
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| Residue: | 690 |
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| Sequence: | MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLP
QRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAE
QAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAG
KRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCF
HNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQ
FGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKS
SRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQAR
AQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNV
TMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHK
ESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNN
VTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAY
QQGTNSKPCFQKKDVEDGNANFLGKASGID
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| Component 2 |
| Name: | Guanylate cyclase soluble subunit beta-1 |
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| Synonyms: | GCYB1_HUMAN | GUC1B3 | GUCSB3 | GUCY1B1 | GUCY1B3 | Guanylate cyclase soluble (GCS-beta-1) | Solube guanylate cyclase beta-1 (sGCβ1) | soluble guanylate cyclase beta-1 (sGC) |
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| Type: | Enzyme |
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| Mol. Mass.: | 70496.05 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q02153 |
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| Residue: | 619 |
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| Sequence: | MYGFVNHALELLVIRNYGPEVWEDIKKEAQLDEEGQFLVRIIYDDSKTYDLVAAASKVLN
LNAGEILQMFGKMFFVFCQESGYDTILRVLGSNVREFLQNLDALHDHLATIYPGMRAPSF
RCTDAEKGKGLILHYYSEREGLQDIVIGIIKTVAQQIHGTEIDMKVIQQRNEECDHTQFL
IEEKESKEEDFYEDLDRFEENGTQESRISPYTFCKAFPFHIIFDRDLVVTQCGNAIYRVL
PQLQPGNCSLLSVFSLVRPHIDISFHGILSHINTVFVLRSKEGLLDVEKLECEDELTGTE
ISCLRLKGQMIYLPEADSILFLCSPSVMNLDDLTRRGLYLSDIPLHDATRDLVLLGEQFR
EEYKLTQELEILTDRLQLTLRALEDEKKKTDTLLYSVLPPSVANELRHKRPVPAKRYDNV
TILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYM
TVSGLPEPCIHHARSICHLALDMMEIAGQVQVDGESVQITIGIHTGEVVTGVIGQRMPRY
CLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENSDPQFHLEHRGPVSMKGKKEPMQ
VWFLSRKNTGTEETKQDDD
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| BDBM50547431 |
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| n/a |
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| Name | BDBM50547431 |
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| Synonyms: | CHEMBL4778917 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H19ClN6O |
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| Mol. Mass. | 370.836 |
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| SMILES | CCCc1nn(-c2nc3NC(=O)C(C)(C)c3c(N)n2)c2ccc(Cl)cc12 |
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| Structure | 
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