| Reaction Details |
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 | Report a problem with these data |
| Target | Acid ceramidase |
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| Ligand | BDBM50556820 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2057398 (CHEMBL4712399) |
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| IC50 | 341±n/a nM |
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| Citation |  Caputo, S; Di Martino, S; Cilibrasi, V; Tardia, P; Mazzonna, M; Russo, D; Penna, I; Summa, M; Bertozzi, SM; Realini, N; Margaroli, N; Migliore, M; Ottonello, G; Liu, M; Lansbury, P; Armirotti, A; Bertorelli, R; Ray, SS; Skerlj, R; Scarpelli, R Design, Synthesis, and Biological Evaluation of a Series of Oxazolone Carboxamides as a Novel Class of Acid Ceramidase Inhibitors. J Med Chem63:15821-15851 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Acid ceramidase |
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| Name: | Acid ceramidase |
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| Synonyms: | ASAH | ASAH1 | ASAH1_HUMAN | Acid ceramidase | Acid ceramidase (AC) |
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| Type: | Enzyme |
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| Mol. Mass.: | 44662.65 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13510 |
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| Residue: | 395 |
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| Sequence: | MPGRSCVALVLLAAAVSCAVAQHAPPWTEDCRKSTYPPSGPTYRGAVPWYTINLDLPPYK
RWHELMLDKAPVLKVIVNSLKNMINTFVPSGKIMQVVDEKLPGLLGNFPGPFEEEMKGIA
AVTDIPLGEIISFNIFYELFTICTSIVAEDKKGHLIHGRNMDFGVFLGWNINNDTWVITE
QLKPLTVNLDFQRNNKTVFKASSFAGYVGMLTGFKPGLFSLTLNERFSINGGYLGILEWI
LGKKDVMWIGFLTRTVLENSTSYEEAKNLLTKTKILAPAYFILGGNQSGEGCVITRDRKE
SLDVYELDAKQGRWYVVQTNYDRWKHPFFLDDRRTPAKMCLNRTSQENISFETMYDVLST
KPVLNKLTVYTTLIDVTKGQFETYLRDCPDPCIGW
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| BDBM50556820 |
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| n/a |
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| Name | BDBM50556820 |
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| Synonyms: | CHEMBL4796255 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H30FN3O3 |
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| Mol. Mass. | 451.5331 |
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| SMILES | CN1CCC(CC1)c1cc(ccc1F)-c1cn(C(=O)NCCCCc2ccccc2)c(=O)o1 |
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| Structure | 
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