| Reaction Details |
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 | Report a problem with these data |
| Target | Probable G-protein coupled receptor 142 |
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| Ligand | BDBM50558180 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2062195 (CHEMBL4717448) |
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| IC50 | 448±n/a nM |
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| Citation |  Wilson, JE; Kurukulasuriya, R; Sinz, C; Lombardo, M; Bender, K; Parker, D; Sherer, EC; Costa, M; Dingley, K; Li, X; Mitelman, S; Tong, S; Bugianesi, R; Ehrhardt, A; Priest, B; Ratliff, K; Ujjainwalla, F; Nargund, R; Hagmann, WK; Edmondson, S Discovery and development of benzo-[1,2,4]-triazolo-[1,4]-oxazepine GPR142 agonists for the treatment of diabetes. Bioorg Med Chem Lett26:2947-2951 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Probable G-protein coupled receptor 142 |
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| Name: | Probable G-protein coupled receptor 142 |
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| Synonyms: | GP142_MOUSE | Gpr142 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 40779.27 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_985965 |
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| Residue: | 365 |
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| Sequence: | MHLNSNPNSYICDAYQHADLLWSLSPHVLTKAVQPQVTLLPTVNGSNPRYDGVDGHWPES
PERSPCVAGIIPVIYYSVLLSLGLPVALARLAARTRKPSYHYLLALTASDIVTQVIIVFV
GFLLQGAVLARQVPQAVVRTANILEFAANHASVWIAVLFTVDRYNALCRPLRHRATSSPG
RTHRAIAAVIGVTLLTGIPFYWWLDVWRDADPPSTMDKLLKWAHCLIVYFIPCNVFLVTN
SAIILRLRKRGQRGLRPLVSKSTAILLGVTSLFALLWAPRIIVMLYHLYVAPVHRDWRVH
LALDIANMLAMLNTEVNFGLYCFISKTFRATVRQVICDVHMACALKSQPKQTVVELMLKS
VGTEL
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| BDBM50558180 |
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| n/a |
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| Name | BDBM50558180 |
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| Synonyms: | CHEMBL4781458 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H19N5O2 |
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| Mol. Mass. | 385.4186 |
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| SMILES | Nc1cc(ccn1)-c1ccc2OCCN(Cc2c1)C(=O)Nc1cccc(c1)C#N |
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| Structure | 
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