Reaction Details |
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Target | Interstitial collagenase |
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Ligand | BDBM50131532 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_106294 |
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IC50 | 880±n/a nM |
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Citation | Levin, JI; Chen, JM; Cheung, K; Cole, D; Crago, C; Santos, ED; Du, X; Khafizova, G; MacEwan, G; Niu, C; Salaski, EJ; Zask, A; Cummons, T; Sung, A; Xu, J; Zhang, Y; Xu, W; Ayral-Kaloustian, S; Jin, G; Cowling, R; Barone, D; Mohler, KM; Black, RA; Skotnicki, JS Acetylenic TACE inhibitors. Part 1. SAR of the acyclic sulfonamide hydroxamates. Bioorg Med Chem Lett13:2799-803 (2003) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Interstitial collagenase |
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Name: | Interstitial collagenase |
Synonyms: | CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1) |
Type: | Enzyme |
Mol. Mass.: | 54010.26 |
Organism: | Homo sapiens (Human) |
Description: | P03956 |
Residue: | 469 |
Sequence: | MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPV
VEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIEN
YTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGN
LAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSY
TFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDR
FYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGY
PKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFP
GIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
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BDBM50131532 |
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n/a |
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Name | BDBM50131532 |
Synonyms: | (R)-2-(4-(but-2-ynyloxy)phenylsulfonamido)-N-hydroxy-3,3-dimethylbutanamide | (R)-2-(4-But-2-ynyloxy-benzenesulfonylamino)-N-hydroxy-3,3-dimethyl-butyramide | CHEMBL317624 |
Type | Small organic molecule |
Emp. Form. | C16H22N2O5S |
Mol. Mass. | 354.421 |
SMILES | CC#CCOc1ccc(cc1)S(=O)(=O)N[C@@H](C(=O)NO)C(C)(C)C |
Structure |
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