| Reaction Details |
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 | Report a problem with these data |
| Target | Carboxypeptidase B2 |
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| Ligand | BDBM50575770 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2125989 (CHEMBL4835334) |
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| EC50 | 378±n/a nM |
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| Citation |  Schaffner, AP; Sansilvestri-Morel, P; Despaux, N; Ruano, E; Persigand, T; Rupin, A; Mennecier, P; Vallez, MO; Raimbaud, E; Desos, P; Gloanec, P Phosphinanes and Azaphosphinanes as Potent and Selective Inhibitors of Activated Thrombin-Activatable Fibrinolysis Inhibitor (TAFIa). J Med Chem64:3897-3910 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Carboxypeptidase B2 |
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| Name: | Carboxypeptidase B2 |
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| Synonyms: | 3.4.17.20 | CBPB2_RAT | CPR | CPU | Carboxypeptidase B2 | Carboxypeptidase R | Carboxypeptidase U | Cpb2 | TAFI | Thrombin-activable fibrinolysis inhibitor |
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| Type: | PROTEIN |
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| Mol. Mass.: | 48839.06 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_120476 |
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| Residue: | 422 |
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| Sequence: | MKLYGLGVLVAIILYEKHGLAFQSGHVLSALPRTSRQVQLLQNLTTTYEVVLWQPVTAEF
IEKKKEVHFFVNASDVNSVKAYLNASRIPFNVLMNNVEDLIQQQTSNDTVSPRASSSYYE
QYHSLNEIYSWIEVITEQHPDMLQKIYIGSSYEKYPLYVLKVSGKEHRVKNAIWIDCGIH
AREWISPAFCLWFIGYVTQFHGKENTYTRLLRHVDFYIMPVMNVDGYDYTWKKNRMWRKN
RSVHMNNRCVGTDLNRNFASKHWCEKGASSFSCSETYCGLYPESEPEVKAVADFLRRNIN
HIKAYISMHSYSQQILFPYSYNRSKSKDHEELSLVASEAVRAIESINKNTRYTHGSGSES
LYLAPGGSDDWIYDLGIKYSFTIELRDTGRYGFLLPERFIKPTCAEALAAVSKIAWHVIR
NS
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| BDBM50575770 |
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| n/a |
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| Name | BDBM50575770 |
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| Synonyms: | CHEMBL4858095 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H30N3O5P |
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| Mol. Mass. | 447.4645 |
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| SMILES | COc1ccc(cn1)-c1ccccc1CN1CCP(O)(=O)[C@@](CCCCN)(C1)C(O)=O |r| |
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| Structure | 
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