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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Gonadotropin-releasing hormone receptor | ||
| Ligand | BDBM50149257 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_71435 (CHEMBL685307) | ||
| Ki | 965±n/a nM | ||
| Citation |  Tucci, FC; Zhu, YF; Guo, Z; Gross, TD; Connors, PJ; Gao, Y; Rowbottom, MW; Struthers, RS; Reinhart, GJ; Xie, Q; Chen, TK; Bozigian, H; Killam Bonneville, AL; Fisher, A; Jin, L; Saunders, J; Chen, C 3-(2-aminoalkyl)-1-(2,6-difluorobenzyl)-5- (2-fluoro-3-methoxyphenyl)-6-methyl-uracils as orally bioavailable antagonists of the human gonadotropin releasing hormone receptor. J Med Chem47:3483-6 (2004) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Gonadotropin-releasing hormone receptor | |||
| Name: | Gonadotropin-releasing hormone receptor | ||
| Synonyms: | GNRHR | GNRHR_HUMAN | GRHR | GnRH receptor | GnRH-R | Gonadotropin releasing hormone 1 (GnRHR1) | Gonadotropin-releasing hormone receptor | Gonadotropin-releasing hormone receptor (GnRH) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 37749.45 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P30968 | ||
| Residue: | 328 | ||
| Sequence: |
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| BDBM50149257 | |||
| n/a | |||
| Name | BDBM50149257 | ||
| Synonyms: | 3-((S)-2-Amino-4-phenyl-butyl)-1-(2,6-difluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione | CHEMBL116576 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C29H28F3N3O3 | ||
| Mol. Mass. | 523.5461 | ||
| SMILES | COc1cccc(c1F)-c1c(C)n(Cc2c(F)cccc2F)c(=O)n(C[C@@H](N)CCc2ccccc2)c1=O |wD:26.28,(13.94,6.45,;12.6,5.67,;12.6,4.13,;13.94,3.36,;13.94,1.82,;12.6,1.04,;11.27,1.82,;11.27,3.36,;9.94,4.14,;9.92,1.07,;9.92,-.48,;11.25,-1.25,;8.59,-1.26,;8.59,-2.81,;9.92,-3.58,;11.25,-2.79,;12.35,-1.69,;12.59,-3.56,;12.59,-5.12,;11.25,-5.89,;9.92,-5.12,;8.58,-5.89,;7.26,-.48,;5.92,-1.25,;7.26,1.07,;5.92,1.84,;4.57,1.08,;3.25,1.85,;4.57,-.47,;3.23,-1.24,;3.23,-2.77,;1.92,-3.53,;1.92,-5.06,;3.25,-5.82,;4.57,-5.05,;4.57,-3.52,;8.59,1.84,;8.6,3.38,)| | ||
| Structure | 
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