| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Telomerase reverse transcriptase |
|---|
| Ligand | BDBM50155652 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_304144 (CHEMBL840260) |
|---|
| EC50 | 5700±n/a nM |
|---|
| Citation |  Harrison, RJ; Reszka, AP; Haider, SM; Romagnoli, B; Morrell, J; Read, MA; Gowan, SM; Incles, CM; Kelland, LR; Neidle, S Evaluation of by disubstituted acridone derivatives as telomerase inhibitors: the importance of G-quadruplex binding. Bioorg Med Chem Lett14:5845-9 (2004) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Telomerase reverse transcriptase |
|---|
| Name: | Telomerase reverse transcriptase |
|---|
| Synonyms: | EST2 | TCS1 | TERT | TERT_HUMAN | TRT |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 127099.03 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1447029 |
|---|
| Residue: | 1132 |
|---|
| Sequence: | MPRAPRCRAVRSLLRSHYREVLPLATFVRRLGPQGWRLVQRGDPAAFRALVAQCLVCVPW
DARPPPAAPSFRQVSCLKELVARVLQRLCERGAKNVLAFGFALLDGARGGPPEAFTTSVR
SYLPNTVTDALRGSGAWGLLLRRVGDDVLVHLLARCALFVLVAPSCAYQVCGPPLYQLGA
ATQARPPPHASGPRRRLGCERAWNHSVREAGVPLGLPAPGARRRGGSASRSLPLPKRPRR
GAAPEPERTPVGQGSWAHPGRTRGPSDRGFCVVSPARPAEEATSLEGALSGTRHSHPSVG
RQHHAGPPSTSRPPRPWDTPCPPVYAETKHFLYSSGDKEQLRPSFLLSSLRPSLTGARRL
VETIFLGSRPWMPGTPRRLPRLPQRYWQMRPLFLELLGNHAQCPYGVLLKTHCPLRAAVT
PAAGVCAREKPQGSVAAPEEEDTDPRRLVQLLRQHSSPWQVYGFVRACLRRLVPPGLWGS
RHNERRFLRNTKKFISLGKHAKLSLQELTWKMSVRDCAWLRRSPGVGCVPAAEHRLREEI
LAKFLHWLMSVYVVELLRSFFYVTETTFQKNRLFFYRKSVWSKLQSIGIRQHLKRVQLRE
LSEAEVRQHREARPALLTSRLRFIPKPDGLRPIVNMDYVVGARTFRREKRAERLTSRVKA
LFSVLNYERARRPGLLGASVLGLDDIHRAWRTFVLRVRAQDPPPELYFVKVDVTGAYDTI
PQDRLTEVIASIIKPQNTYCVRRYAVVQKAAHGHVRKAFKSHVSTLTDLQPYMRQFVAHL
QETSPLRDAVVIEQSSSLNEASSGLFDVFLRFMCHHAVRIRGKSYVQCQGIPQGSILSTL
LCSLCYGDMENKLFAGIRRDGLLLRLVDDFLLVTPHLTHAKTFLRTLVRGVPEYGCVVNL
RKTVVNFPVEDEALGGTAFVQMPAHGLFPWCGLLLDTRTLEVQSDYSSYARTSIRASLTF
NRGFKAGRNMRRKLFGVLRLKCHSLFLDLQVNSLQTVCTNIYKILLLQAYRFHACVLQLP
FHQQVWKNPTFFLRVISDTASLCYSILKAKNAGMSLGAKGAAGPLPSEAVQWLCHQAFLL
KLTRHRVTYVPLLGSLRTAQTQLSRKLPGTTLTALEAAANPALPSDFKTILD
|
|
|
|---|
| BDBM50155652 |
|---|
| n/a |
|---|
| Name | BDBM50155652 |
|---|
| Synonyms: | 3-Diethylamino-N-[6-(3-diethylamino-propionylamino)-9-oxo-9,10-dihydro-acridin-3-yl]-propionamide | CHEMBL1080436 | CHEMBL362887 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C27H37N5O3 |
|---|
| Mol. Mass. | 479.6144 |
|---|
| SMILES | CCN(CC)CCC(=O)Nc1ccc2c(O)c3ccc(NC(=O)CCN(CC)CC)cc3nc2c1 |
|---|
| Structure | 
|
|---|
Search and Browse
