Reaction Details |
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Target | Gag-Pol polyprotein [489-587] |
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Ligand | BDBM50156914 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_429830 (CHEMBL915411) |
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Ki | 1500±n/a nM |
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Citation | Merabet, N; Dumond, J; Collinet, B; Van Baelinghem, L; Boggetto, N; Ongeri, S; Ressad, F; Reboud-Ravaux, M; Sicsic, S New constrained"molecular tongs" designed to dissociate HIV-1 protease dimer. J Med Chem47:6392-400 (2004) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Gag-Pol polyprotein [489-587] |
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Name: | Gag-Pol polyprotein [489-587] |
Synonyms: | Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol |
Type: | Enzyme Subunit |
Mol. Mass.: | 10781.16 |
Organism: | Human immunodeficiency virus type 1 |
Description: | P04585[489-587] |
Residue: | 99 |
Sequence: | PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
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BDBM50156914 |
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n/a |
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Name | BDBM50156914 |
Synonyms: | (S)-methyl 2-((S)-2-((S)-2-(4-(7-(4-((2S,3S)-1-((2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-ylamino)-3-methyl-1-oxopentan-2-ylamino)-4-oxobutoxy)naphthalen-2-yloxy)butanamido)-3-methylbutanamido)-4-methylpentanamido)-3-methylbutanoate | CHEMBL222971 |
Type | Small organic molecule |
Emp. Form. | C45H70N6O11 |
Mol. Mass. | 871.0709 |
SMILES | CC[C@H](C)[C@H](NC(=O)CCCOc1ccc2ccc(OCCCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)OC)cc2c1)C(=O)N[C@@H]([C@@H](C)O)C(N)=O |r| |
Structure |
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