| Reaction Details |
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 | Report a problem with these data |
| Target | Bromodomain-containing protein 2 |
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| Ligand | BDBM50603097 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2243030 (CHEMBL5157240) |
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| Kd | 7.9±n/a nM |
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| Citation |  Humphreys, PG; Atkinson, SJ; Bamborough, P; Bit, RA; Chung, CW; Craggs, PD; Cutler, L; Davis, R; Ferrie, A; Gong, G; Gordon, LJ; Gray, M; Harrison, LA; Hayhow, TG; Haynes, A; Henley, N; Hirst, DJ; Holyer, ID; Lindon, MJ; Lovatt, C; Lugo, D; McCleary, S; Molnar, J; Osmani, Q; Patten, C; Preston, A; Rioja, I; Seal, JT; Smithers, N; Sun, F; Tang, D; Taylor, S; Theodoulou, NH; Thomas, C; Watson, RJ; Wellaway, CR; Zhu, L; Tomkinson, NCO; Prinjha, RK Design, Synthesis, and Characterization of I-BET567, a Pan-Bromodomain and Extra Terminal (BET) Bromodomain Oral Candidate. J Med Chem65:2262-2287 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Bromodomain-containing protein 2 |
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| Name: | Bromodomain-containing protein 2 |
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| Synonyms: | BRD2 | BRD2_HUMAN | Bromodomain and extra-terminal motif (BET) | Bromodomain-containing protein 2 | Bromodomain-containing protein 2 (BRD2) | KIAA9001 | RING3 |
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| Type: | Protein |
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| Mol. Mass.: | 88085.95 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P25440 |
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| Residue: | 801 |
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| Sequence: | MLQNVTPHNKLPGEGNAGLLGLGPEAAAPGKRIRKPSLLYEGFESPTMASVPALQLTPAN
PPPPEVSNPKKPGRVTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQP
MDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASM
PQEEQELVVTIPKNSHKKGAKLAALQGSVTSAHQVPAVSSVSHTALYTPPPEIPTTVLNI
PHPSVISSPLLKSLHSAGPPLLAVTAAPPAQPLAKKKGVKRKADTTTPTPTAILAPGSPA
SPPGSLEPKAARLPPMRRESGRPIKPPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKEL
LSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRL
MFSNCYKYNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTAMPPGLAKSSSES
SSEESSSESSSEEEEEEDEEDEEEEESESSDSEEERAHRLAELQEQLRAVHEQLAALSQG
PISKPKRKREKKEKKKKRKAEKHRGRAGADEDDKGPRAPRPPQPKKSKKASGSGGGSAAL
GPSGFGPSGGSGTKLPKKATKTAPPALPTGYDSEEEEESRPMSYDEKRQLSLDINKLPGE
KLGRVVHIIQAREPSLRDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPYTIKKP
VGKTKEELALEKKRELEKRLQDVSGQLNSTKKPPKKANEKTESSSAQQVAVSRLSASSSS
SDSSSSSSSSSSSDTSDSDSG
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| BDBM50603097 |
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| n/a |
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| Name | BDBM50603097 |
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| Synonyms: | CHEMBL5195288 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H18ClN5O2 |
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| Mol. Mass. | 359.81 |
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| SMILES | C[C@H]1C[C@@H](Nc2ncc(Cl)cn2)c2cc(ccc2N1C(C)=O)C(N)=O |r| |
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| Structure | 
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