Reaction Details |
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Target | Indoleamine 2,3-dioxygenase 1 |
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Ligand | BDBM50606610 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2260710 (CHEMBL5215721) |
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IC50 | 4120±n/a nM |
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Citation | Ning, XL; Li, YZ; Huo, C; Deng, J; Gao, C; Zhu, KR; Wang, M; Wu, YX; Yu, JL; Ren, YL; Luo, ZY; Li, G; Chen, Y; Wang, SY; Peng, C; Yang, LL; Wang, ZY; Wu, Y; Qian, S; Li, GB X-ray Structure-Guided Discovery of a Potent, Orally Bioavailable, Dual Human Indoleamine/Tryptophan 2,3-Dioxygenase (hIDO/hTDO) Inhibitor That Shows Activity in a Mouse Model of Parkinson's Disease. J Med Chem64:8303-8332 (2021) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Indoleamine 2,3-dioxygenase 1 |
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Name: | Indoleamine 2,3-dioxygenase 1 |
Synonyms: | I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase |
Type: | Enzyme |
Mol. Mass.: | 45330.80 |
Organism: | Homo sapiens (Human) |
Description: | P14902 |
Residue: | 403 |
Sequence: | MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVE
KLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLEL
PPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKV
IPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGN
PQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMP
PAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQ
QPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
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BDBM50606610 |
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n/a |
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Name | BDBM50606610 |
Synonyms: | CHEMBL5220677 |
Type | Small organic molecule |
Emp. Form. | C14H18BrN3O |
Mol. Mass. | 324.216 |
SMILES | OC1CCCCC1CNc1cc(Br)cc2[nH]ncc12 |
Structure |
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