| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cathepsin K |
|---|
| Ligand | BDBM50253097 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_539146 (CHEMBL1023823) |
|---|
| IC50 | 9.3±n/a nM |
|---|
| Citation |  Robichaud, J; Black, WC; Thérien, M; Paquet, J; Oballa, RM; Bayly, CI; McKay, DJ; Wang, Q; Isabel, E; Léger, S; Mellon, C; Kimmel, DB; Wesolowski, G; Percival, MD; Massé, F; Desmarais, S; Falgueyret, JP; Crane, SN Identification of a nonbasic, nitrile-containing cathepsin K inhibitor (MK-1256) that is efficacious in a monkey model of osteoporosis. J Med Chem51:6410-20 (2008) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cathepsin K |
|---|
| Name: | Cathepsin K |
|---|
| Synonyms: | CATK_RABIT | CTSK |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 36879.51 |
|---|
| Organism: | Oryctolagus cuniculus (rabbit) |
|---|
| Description: | n/a |
|---|
| Residue: | 329 |
|---|
| Sequence: | MWGLKVLLLPVVSFALHPEEILDTQWELWKKTYSKQYNSKVDEISRRLIWEKNLKHISIH
NLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPPSRSHSNDTLYIPDWEGRTPDSID
YRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENYGCGGG
YMTNAFQYVQRNRGIDSEDAYPYVGQDESCMYNPTGKAAKCRGYREIPEGNEKALKRAVA
RVGPVSVAIDASLTSFQFYSKGVYYDENCSSDNVNHAVLAVGYGIQKGNKHWIIKNSWGE
SWGNKGYILMARNKNNACGIANLASFPKM
|
|
|
|---|
| BDBM50253097 |
|---|
| n/a |
|---|
| Name | BDBM50253097 |
|---|
| Synonyms: | (1R,2R)-N-(1-cyanocyclopropyl)-5,5-difluoro-2-(4-(4-(methylsulfonyl)phenyl)-1-(2,2,2-trifluoroethyl)-1H-pyrazol-3-yl)cyclohexanecarboxamide | CHEMBL495113 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H23F5N4O3S |
|---|
| Mol. Mass. | 530.511 |
|---|
| SMILES | CS(=O)(=O)c1ccc(cc1)-c1cn(CC(F)(F)F)nc1[C@@H]1CCC(F)(F)C[C@H]1C(=O)NC1(CC1)C#N |r| |
|---|
| Structure | 
|
|---|
Search and Browse
