| Reaction Details |
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 | Report a problem with these data |
| Target | Cathepsin K |
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| Ligand | BDBM19909 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_539146 (CHEMBL1023823) |
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| IC50 | 0.41±n/a nM |
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| Citation |  Robichaud, J; Black, WC; Thérien, M; Paquet, J; Oballa, RM; Bayly, CI; McKay, DJ; Wang, Q; Isabel, E; Léger, S; Mellon, C; Kimmel, DB; Wesolowski, G; Percival, MD; Massé, F; Desmarais, S; Falgueyret, JP; Crane, SN Identification of a nonbasic, nitrile-containing cathepsin K inhibitor (MK-1256) that is efficacious in a monkey model of osteoporosis. J Med Chem51:6410-20 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cathepsin K |
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| Name: | Cathepsin K |
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| Synonyms: | CATK_RABIT | CTSK |
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| Type: | Enzyme |
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| Mol. Mass.: | 36879.51 |
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| Organism: | Oryctolagus cuniculus (rabbit) |
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| Description: | n/a |
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| Residue: | 329 |
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| Sequence: | MWGLKVLLLPVVSFALHPEEILDTQWELWKKTYSKQYNSKVDEISRRLIWEKNLKHISIH
NLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPPSRSHSNDTLYIPDWEGRTPDSID
YRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENYGCGGG
YMTNAFQYVQRNRGIDSEDAYPYVGQDESCMYNPTGKAAKCRGYREIPEGNEKALKRAVA
RVGPVSVAIDASLTSFQFYSKGVYYDENCSSDNVNHAVLAVGYGIQKGNKHWIIKNSWGE
SWGNKGYILMARNKNNACGIANLASFPKM
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| BDBM19909 |
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| n/a |
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| Name | BDBM19909 |
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| Synonyms: | (1R,2R)-N-(cyanomethyl)-5,5-difluoro-2-{1-methyl-4-[4-(methylsulfanyl)phenyl]-1H-pyrazol-3-yl}cyclohexane-1-carboxamide | CHEMBL492654 | beta-substituted cyclohexanecarboxamide, 10 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H22F2N4OS |
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| Mol. Mass. | 404.477 |
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| SMILES | CSc1ccc(cc1)-c1cn(C)nc1[C@@H]1CCC(F)(F)C[C@H]1C(=O)NCC#N |r| |
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| Structure | 
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