Reaction Details |
| Report a problem with these data |
Target | Hexokinase-4 |
---|
Ligand | BDBM50256900 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_566834 (CHEMBL957643) |
---|
EC50 | 490±n/a nM |
---|
Citation | Iino, T; Tsukahara, D; Kamata, K; Sasaki, K; Ohyama, S; Hosaka, H; Hasegawa, T; Chiba, M; Nagata, Y; Eiki, J; Nishimura, T Discovery of potent and orally active 3-alkoxy-5-phenoxy-N-thiazolyl benzamides as novel allosteric glucokinase activators. Bioorg Med Chem17:2733-43 (2009) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Hexokinase-4 |
---|
Name: | Hexokinase-4 |
Synonyms: | GCK | Glucokinase (GCK) | Glucokinase (GK) | Glucokinase/Glucokinase regulatory protein | HK IV | HK4 | HXK4_HUMAN | Hexokinase-4 | Hexokinase-D |
Type: | Enzyme |
Mol. Mass.: | 52175.81 |
Organism: | Homo sapiens (Human) |
Description: | P35557 |
Residue: | 465 |
Sequence: | MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPT
YVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAE
MLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNN
VVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQN
VELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGE
LVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPS
TTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFK
ERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
|
|
|
BDBM50256900 |
---|
n/a |
---|
Name | BDBM50256900 |
Synonyms: | 3-(2-Methoxyphenoxy)-N-(4-methyl-1,3-thiazol-2-yl)benzamid | CHEMBL475032 |
Type | Small organic molecule |
Emp. Form. | C18H16N2O3S |
Mol. Mass. | 340.396 |
SMILES | COc1ccccc1Oc1cccc(c1)C(=O)Nc1nc(C)cs1 |
Structure |
|