Reaction Details |
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Target | Serine/threonine-protein kinase Sgk1 |
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Ligand | BDBM50296004 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_579226 (CHEMBL1058020) |
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IC50 | 63±n/a nM |
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Citation | Hammond, M; Washburn, DG; Hoang, HT; Manns, S; Frazee, JS; Nakamura, H; Patterson, JR; Trizna, W; Wu, C; Azzarano, LM; Nagilla, R; Nord, M; Trejo, R; Head, MS; Zhao, B; Smallwood, AM; Hightower, K; Laping, NJ; Schnackenberg, CG; Thompson, SK Design and synthesis of orally bioavailable serum and glucocorticoid-regulated kinase 1 (SGK1) inhibitors. Bioorg Med Chem Lett19:4441-5 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Serine/threonine-protein kinase Sgk1 |
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Name: | Serine/threonine-protein kinase Sgk1 |
Synonyms: | SGK | SGK1 | SGK1_HUMAN | Serine/threonine-protein kinase Sgk1 | Serine/threonine-protein kinase Sgk1 (SGK) | Serum/glucocorticoid regulated kinase | Serum/glucocorticoid-regulated kinase 1 (SGK1) |
Type: | Other Protein Type |
Mol. Mass.: | 48954.40 |
Organism: | Homo sapiens (Human) |
Description: | Recombinant human SGK-1 enzyme produced in a baculovirus system. |
Residue: | 431 |
Sequence: | MTVKTEAAKGTLTYSRMRGMVAILIAFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKI
SQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAE
EVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYIN
GGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTD
FGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSR
NTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINW
DDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLG
FSYAPPTDSFL
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BDBM50296004 |
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n/a |
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Name | BDBM50296004 |
Synonyms: | 2-(4-(5-(naphthalen-2-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl)acetic acid | CHEMBL549906 | [4-(5-naphthalen-2-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl]acetic acid |
Type | Small organic molecule |
Emp. Form. | C25H18N2O2 |
Mol. Mass. | 378.4226 |
SMILES | OC(=O)Cc1ccc(cc1)-c1c[nH]c2ncc(cc12)-c1ccc2ccccc2c1 |
Structure |
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