| Reaction Details |
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 | Report a problem with these data |
| Target | Diacylglycerol O-acyltransferase 1 |
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| Ligand | BDBM50354629 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_771071 (CHEMBL1838732) |
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| IC50 | 30±n/a nM |
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| Citation |  Motiwala, H; Kandre, S; Birar, V; Kadam, KS; Rodge, A; Jadhav, RD; Mahesh Kumar Reddy, M; Brahma, MK; Deshmukh, NJ; Dixit, A; Doshi, L; Gupte, A; Gangopadhyay, AK; Vishwakarma, RA; Srinivasan, S; Sharma, M; Nemmani, KV; Sharma, R Exploration of pyridine containing heteroaryl analogs of biaryl ureas as DGAT1 inhibitors. Bioorg Med Chem Lett21:5812-7 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Diacylglycerol O-acyltransferase 1 |
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| Name: | Diacylglycerol O-acyltransferase 1 |
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| Synonyms: | ACAT-related gene product 1 | AGRP1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | DGAT | DGAT1 | DGAT1_HUMAN | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase |
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| Type: | Protein |
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| Mol. Mass.: | 55297.82 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O75907 |
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| Residue: | 488 |
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| Sequence: | MGDRGSSRRRRTGSRPSSHGGGGPAAAEEEVRDAAAGPDVGAAGDAPAPAPNKDGDAGVG
SGHWELRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQV
VSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALTEQAGLLLHVANLATILCFPA
AVVLLVESITPVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKASSAAAPHT
VSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEMLFFTQLQVGLIQQWM
VPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREF
YRDWWNSESVTYFWQNWNIPVHKWCIRHFYKPMLRRGSSKWMARTGVFLASAFFHEYLVS
VPLRMFRLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDYYVLN
YEAPAAEA
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| BDBM50354629 |
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| n/a |
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| Name | BDBM50354629 |
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| Synonyms: | CHEMBL1834431 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H18N4O4 |
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| Mol. Mass. | 390.392 |
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| SMILES | OC(=O)CNC(=O)c1ccc(cc1)-c1ccc(NC(=O)Nc2ccccc2)nc1 |
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| Structure | 
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