Reaction Details |
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Target | Tyrosine-protein phosphatase non-receptor type 2 |
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Ligand | BDBM50362181 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_798052 (CHEMBL1943107) |
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IC50 | 580±n/a nM |
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Citation | Patel, D; Jain, M; Shah, SR; Bahekar, R; Jadav, P; Joharapurkar, A; Dhanesha, N; Shaikh, M; Sairam, KV; Kapadnis, P Discovery of potent, selective and orally bioavailable triaryl-sulfonamide based PTP1B inhibitors. Bioorg Med Chem Lett22:1111-7 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein phosphatase non-receptor type 2 |
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Name: | Tyrosine-protein phosphatase non-receptor type 2 |
Synonyms: | PTN2_HUMAN | PTPN2 | PTPT | T-cell protein tyrosine phosphatase (TCPTP) | T-cell protein-tyrosine phosphatase | TC-PTP | TCPTP | Tyrosine-protein phosphatase non-receptor type 2 | Tyrosine-protein phosphatase non-receptor type 2 (TC-PTP) |
Type: | Protein |
Mol. Mass.: | 48481.80 |
Organism: | Homo sapiens (Human) |
Description: | P17706 |
Residue: | 415 |
Sequence: | MPTTIEREFEELDTQRRWQPLYLEIRNESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVK
LQNAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKES
VKCAQYWPTDDQEMLFKETGFSVKLLSEDVKSYYTVHLLQLENINSGETRTISHFHYTTW
PDFGVPESPASFLNFLFKVRESGSLNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGD
DINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAKCIKGDSSIQKRWKELSKEDLSPA
FDHSPNKIMTEKYNGNRIGLEEEKLTGDRCTGLSSKMQDTMEENSESALRKRIREDRKAT
TAQKVQQMKQRLNENERKRKRWLYWQPILTKMGFMSVILVGAFVGWTLFFQQNAL
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BDBM50362181 |
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n/a |
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Name | BDBM50362181 |
Synonyms: | ({7-[2-(1H-1,2,3-benzotriazol-1-yl)-2-({6-bromo-7-[difluoro(phosphono)methyl]naphthalen-2-yl}methyl)-3-oxo-3-phenylpropyl]-3-bromonaphthalen-2-yl}difluoromethyl)phosphonic acid (10h) | CHEMBL1938814 |
Type | Small organic molecule |
Emp. Form. | C38H27Br2F4N3O7P2 |
Mol. Mass. | 935.386 |
SMILES | OP(O)(=O)C(F)(F)c1cc2cc(CC(Cc3ccc4cc(Br)c(cc4c3)C(F)(F)P(O)(O)=O)(C(=O)c3ccccc3)n3nnc4ccccc34)ccc2cc1Br |
Structure |
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