| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Inhibitor of nuclear factor kappa-B kinase subunit beta |
|---|
| Ligand | BDBM50124330 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_90394 |
|---|
| IC50 | 1800±n/a nM |
|---|
| Citation |  Murata, T; Shimada, M; Sakakibara, S; Yoshino, T; Kadono, H; Masuda, T; Shimazaki, M; Shintani, T; Fuchikami, K; Sakai, K; Inbe, H; Takeshita, K; Niki, T; Umeda, M; Bacon, KB; Ziegelbauer, KB; Lowinger, TB Discovery of novel and selective IKK-beta serine-threonine protein kinase inhibitors. Part 1. Bioorg Med Chem Lett13:913-8 (2003) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Inhibitor of nuclear factor kappa-B kinase subunit beta |
|---|
| Name: | Inhibitor of nuclear factor kappa-B kinase subunit beta |
|---|
| Synonyms: | I-kappa-B Kinase 2 (IKK-beta) | I-kappa-B kinase 2 | I-kappa-B-kinase beta | I-kappa-B-kinase beta (IKKB) | IKBKB | IKK-B | IKK-beta | IKK2 | IKK2/IKK1 | IKKB | IKKB_HUMAN | Inhibitor of NF-kappa-B kinase alpha/beta | Inhibitor of nuclear factor kappa B kinase beta subunit | NFKBIKB | Nuclear factor NF-kappa-B inhibitor kinase beta |
|---|
| Type: | Serine/threonine-protein kinase |
|---|
| Mol. Mass.: | 86554.39 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | GST-tagged IKK-2 was expressed in High Five cells and purified. |
|---|
| Residue: | 756 |
|---|
| Sequence: | MSWSPSLTTQTCGAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCL
EIQIMRRLTHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREG
AILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCT
SFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSE
VDIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPTYGPNGCF
KALDDILNLKLVHILNMVTGTIHTYPVTEDESLQSLKARIQQDTGIPEEDQELLQEAGLA
LIPDKPATQCISDGKLNEGHTLDMDLVFLFDNSKITYETQISPRPQPESVSCILQEPKRN
LAFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMMNLLRNNSCLSKMKNSMASMSQQLK
AKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAVELCGRENEVKLLVERMMAL
QTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLREKPRDQRTEGDSQEMVRLLLQAIQS
FEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLMNEDEKTVVRLQEKRQKELWNLLKI
ACSKVRGPVSGSPDSMNASRLSQPGQLMSQPSTASNSLPEPAKKSEELVAEAHNLCTLLE
NAIQDTVREQDQSFTALDWSWLQTEEEEHSCLEQAS
|
|
|
|---|
| BDBM50124330 |
|---|
| n/a |
|---|
| Name | BDBM50124330 |
|---|
| Synonyms: | 3-[2-Amino-3-cyano-6-(2-hydroxy-phenyl)-pyridin-4-yl]-N-(2-piperidin-1-yl-ethyl)-benzamide | CHEMBL174140 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H27N5O2 |
|---|
| Mol. Mass. | 441.5249 |
|---|
| SMILES | Nc1nc(cc(-c2cccc(c2)C(=O)NCCN2CCCCC2)c1C#N)-c1ccccc1O |
|---|
| Structure | 
|
|---|
Search and Browse
