Reaction Details |
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Target | Neutrophil elastase |
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Ligand | BDBM50005157 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_63659 |
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IC50 | >5000±n/a nM |
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Citation | Skiles, JW; Fuchs, V; Miao, C; Sorcek, R; Grozinger, KG; Mauldin, SC; Vitous, J; Mui, PW; Jacober, S; Chow, G Inhibition of human leukocyte elastase (HLE) by N-substituted peptidyl trifluoromethyl ketones. J Med Chem35:641-62 (1992) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Neutrophil elastase |
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Name: | Neutrophil elastase |
Synonyms: | Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin |
Type: | Enzyme |
Mol. Mass.: | 28532.38 |
Organism: | Homo sapiens (Human) |
Description: | P08246 |
Residue: | 267 |
Sequence: | MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
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BDBM50005157 |
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n/a |
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Name | BDBM50005157 |
Synonyms: | (1-{Indan-2-yl-[2-(3,3,3-trifluoro-1-isopropyl-2-oxo-propylamino)-ethyl]-carbamoyl}-2-methyl-propyl)-carbamic acid tert-butyl ester | CHEMBL160948 |
Type | Small organic molecule |
Emp. Form. | C27H40F3N3O4 |
Mol. Mass. | 527.6194 |
SMILES | CC(C)C(NCCN(C1Cc2ccccc2C1)C(=O)C(NC(=O)OC(C)(C)C)C(C)C)C(=O)C(F)(F)F |
Structure |
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