| Reaction Details |
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 | Report a problem with these data |
| Target | Gastrin/cholecystokinin type B receptor |
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| Ligand | BDBM50422178 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_47816 (CHEMBL660030) |
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| IC50 | 1900±n/a nM |
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| Citation |  Boteju, LW; Nikiforovich, GV; Haskell-Luevano, C; Fang, SN; Zalewska, T; Stropova, D; Yamamura, HI; Hruby, VJ The use of topographical constraints in receptor mapping: investigation of the topographical requirements of the tryptophan 30 residue for receptor binding of Asp-Tyr-D-Phe-Gly-Trp-(N-Me)Nle-Asp-Phe-NH2 (SNF 9007), a cholecystokinin (26-33) analogue that binds to both CCK-B and delta-opioid recepto J Med Chem39:4120-4 (1996) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Gastrin/cholecystokinin type B receptor |
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| Name: | Gastrin/cholecystokinin type B receptor |
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| Synonyms: | CCK-2 receptor | CCK-B receptor | CCK-BR | CCKBR | CCKRB | Cholecystokinin A | Cholecystokinin receptor | Cholecystokinin-2 Receptor | GASR_HUMAN | Gastrin/cholecystokinin type B receptor |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 48445.79 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Stable expression of human CCK-2 receptors in HEK 293 cells. |
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| Residue: | 447 |
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| Sequence: | MELLKLNRSVQGTGPGPGASLCRPGAPLLNSSSVGNLSCEPPRIRGAGTRELELAIRITL
YAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTF
IFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARVIVATWL
LSGLLMVPYPVYTVVQPVGPRVLQCVHRWPSARVRQTWSVLLLLLLFFIPGVVMAVAYGL
ISRELYLGLRFDGDSDSDSQSRVRNQGGLPGAVHQNGRCRPETGAVGEDSDGCYVQLPRS
RPALELTALTAPGPGSGSRPTQAKLLAKKRVVRMLLVIVVLFFLCWLPVYSANTWRAFDG
PGAHRALSGAPISFIHLLSYASACVNPLVYCFMHRRFRQACLETCARCCPRPPRARPRAL
PDEDPPTPSIASLSRLSYTTISTLGPG
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| BDBM50422178 |
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| n/a |
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| Name | BDBM50422178 |
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| Synonyms: | CHEMBL2112688 |
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| Type | Small organic molecule |
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| Emp. Form. | C56H68N10O13 |
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| Mol. Mass. | 1089.1983 |
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| SMILES | CCCC[C@H](N(C)C(=O)[C@@H](NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(O)=O)[C@H](C)c1c[nH]c2ccccc12)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O |
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| Structure | 
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