| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase Lck |
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| Ligand | BDBM50101669 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_221650 (CHEMBL823227) |
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| Kd | 280±n/a nM |
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| Citation |  Proudfoot, JR; Betageri, R; Cardozo, M; Gilmore, TA; Glynn, S; Hickey, ER; Jakes, S; Kabcenell, A; Kirrane, TM; Tibolla, AK; Lukas, S; Patel, UR; Sharma, R; Yazdanian, M; Moss, N; Beaulieu, PL; Cameron, DR; Ferland, JM; Gauthier, J; Gillard, J; Gorys, V; Poirier, M; Rancourt, J; Wernic, D; Llinas-Brunet, M Nonpeptidic, monocharged, cell permeable ligands for the p56lck SH2 domain. J Med Chem44:2421-31 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase Lck |
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| Name: | Tyrosine-protein kinase Lck |
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| Synonyms: | 2.7.10.2 | LCK | LCK_HUMAN | LSK | Leukocyte C-terminal Src kinase | Lymphocyte cell-specific protein-tyrosine kinase | Lymphocyte-specific protein tyrosine kinase | P56-LCK | Protein YT16 | Proto-oncogene Lck | Proto-oncogene tyrosine-protein kinase LCK | Src/Lck kinase | T cell-specific protein-tyrosine kinase |
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| Type: | n/a |
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| Mol. Mass.: | 57987.83 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P06239 |
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| Residue: | 509 |
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| Sequence: | MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASP
LQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKAN
SLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKH
YKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEV
PRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRL
VRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNY
IHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIK
SDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKER
PEDRPTFDYLRSVLEDFFTATEGQYQPQP
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| BDBM50101669 |
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| n/a |
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| Name | BDBM50101669 |
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| Synonyms: | (RS)2-{4-[2-[1-(4-Methoxy-benzyl)-4-methyl-2-oxo-2,3-dihydro-pyridin-3-ylcarbamoyl]-2-(2-naphthalen-2-yl-acetylamino)-ethyl]-phenyl}-2-methyl-propionic acid | CHEMBL79648 |
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| Type | Small organic molecule |
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| Emp. Form. | C39H39N3O6 |
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| Mol. Mass. | 645.7435 |
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| SMILES | COc1ccc(Cn2ccc(C)c(NC(=O)C(Cc3ccc(cc3)C(C)(C)C(O)=O)NC(=O)Cc3ccc4ccccc4c3)c2=O)cc1 |
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| Structure | 
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