| Reaction Details |
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 | Report a problem with these data |
| Target | Neutrophil elastase |
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| Ligand | BDBM19492 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_508157 (CHEMBL1008215) |
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| IC50 | >50000±n/a nM |
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| Citation |  Méthot, N; Rubin, J; Guay, D; Beaulieu, C; Ethier, D; Reddy, TJ; Riendeau, D; Percival, MD Inhibition of the activation of multiple serine proteases with a cathepsin C inhibitor requires sustained exposure to prevent pro-enzyme processing. J Biol Chem282:20836-46 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neutrophil elastase |
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| Name: | Neutrophil elastase |
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| Synonyms: | ELNE_MOUSE | Ela2 | Elane |
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| Type: | PROTEIN |
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| Mol. Mass.: | 28661.19 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_1463437 |
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| Residue: | 265 |
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| Sequence: | MALGRLSSRTLAAMLLALFLGGPALASEIVGGRPARPHAWPFMASLQRRGGHFCGATLIA
RNFVMSAAHCVNGLNFRSVQVVLGAHDLRRQERTRQTFSVQRIFENGFDPSQLLNDIVII
QLNGSATINANVQVAQLPAQGQGVGDRTPCLAMGWGRLGTNRPSPSVLQELNVTVVTNMC
RRRVNVCTLVPRRQAGICFGDSGGPLVCNNLVQGIDSFIRGGCGSGLYPDAFAPVAEFAD
WINSIIRSHNDHLLTHPKDREGRTN
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| BDBM19492 |
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| n/a |
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| Name | BDBM19492 |
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| Synonyms: | (2R)-2-{[(1S)-1-(4-bromophenyl)-2,2,2-trifluoroethyl]amino}-N-(1-cyanocyclopropyl)-3-methanesulfonylpropanamide | CHEMBL400387 | trifluoroethylamine inhibitor, 2 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H17BrF3N3O3S |
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| Mol. Mass. | 468.289 |
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| SMILES | CS(=O)(=O)C[C@H](N[C@@H](c1ccc(Br)cc1)C(F)(F)F)C(=O)NC1(CC1)C#N |r| |
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| Structure | 
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