Reaction Details |
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Target | Serine/threonine-protein kinase pim-1 |
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Ligand | BDBM50384715 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_820887 (CHEMBL2038828) |
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IC50 | 5±n/a nM |
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Citation | Haddach, M; Michaux, J; Schwaebe, MK; Pierre, F; Borsan, C; Tran, J; Raffaele, N; Ravula, S; Drygin, D; Siddiqui-Jain, A; Darjania, L; Stansfield, R; Proffitt, C; Macalino, D; Streiner, N; Bliesath, J; Omori, M; Whitten, JP; Anderes, K; Rice, WG; Ryckman, DM Discovery of CX-6258. A Potent, Selective, and Orally Efficacious pan-Pim Kinases Inhibitor. ACS Med Chem Lett3:135-139 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Serine/threonine-protein kinase pim-1 |
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Name: | Serine/threonine-protein kinase pim-1 |
Synonyms: | PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1) |
Type: | Protein |
Mol. Mass.: | 35681.82 |
Organism: | Homo sapiens (Human) |
Description: | P11309 |
Residue: | 313 |
Sequence: | MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSD
NLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLIL
ERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRG
ELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDI
PFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETA
EIHLHSLSPGPSK
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BDBM50384715 |
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n/a |
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Name | BDBM50384715 |
Synonyms: | CHEMBL2037201 |
Type | Small organic molecule |
Emp. Form. | C25H22ClN3O3 |
Mol. Mass. | 447.913 |
SMILES | Clc1ccc2NC(=O)\C(=C\c3ccc(o3)-c3cccc(c3)C(=O)N3CCCNCC3)c2c1 |
Structure |
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