Found 45 hits with Last Name = 'darjania' and Initial = 'l' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM50384714
(CHEMBL2037200)Show SMILES CN1CCCN(CC1)C(=O)c1cccc(c1)-c1ccc(\C=C2\C(=O)Nc3ccc(Cl)cc23)o1 Show InChI InChI=1S/C26H24ClN3O3/c1-29-10-3-11-30(13-12-29)26(32)18-5-2-4-17(14-18)24-9-7-20(33-24)16-22-21-15-19(27)6-8-23(21)28-25(22)31/h2,4-9,14-16H,3,10-13H2,1H3,(H,28,31)/b22-16+ | PDB
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| 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Reversible inhibition of human recombinant Pim1 using RSRHSSYPAGT as substrate |
ACS Med Chem Lett 3: 135-139 (2012)
Article DOI: 10.1021/ml200259q
BindingDB Entry DOI: 10.7270/Q2X92CBW |
More data for this
Ligand-Target Pair | |
Casein kinase II subunit alpha
(Homo sapiens (Human)) | BDBM50335638
(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)Show SMILES OC(=O)c1ccc2c(c1)nc(Nc1cccc(Cl)c1)c1ccncc21 Show InChI InChI=1S/C19H12ClN3O2/c20-12-2-1-3-13(9-12)22-18-15-6-7-21-10-16(15)14-5-4-11(19(24)25)8-17(14)23-18/h1-10H,(H,22,23)(H,24,25) | PDB
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| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Cylene Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant CK2alpha by radiometric assay |
J Med Chem 54: 635-54 (2011)
Article DOI: 10.1021/jm101251q
BindingDB Entry DOI: 10.7270/Q2J67H7N |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Casein kinase II subunit alpha
(Homo sapiens (Human)) | BDBM50335638
(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)Show SMILES OC(=O)c1ccc2c(c1)nc(Nc1cccc(Cl)c1)c1ccncc21 Show InChI InChI=1S/C19H12ClN3O2/c20-12-2-1-3-13(9-12)22-18-15-6-7-21-10-16(15)14-5-4-11(19(24)25)8-17(14)23-18/h1-10H,(H,22,23)(H,24,25) | PDB
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| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Cylene Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant CK2alpha at enzyme-substrate complex by radiometric assay |
J Med Chem 54: 635-54 (2011)
Article DOI: 10.1021/jm101251q
BindingDB Entry DOI: 10.7270/Q2J67H7N |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM50384706
(CHEMBL2037204)Show SMILES CN1CCCN(CC1)C(=O)c1ccc(F)c(c1)-c1ccc(\C=C2\C(=O)Nc3ccc(Cl)cc23)o1 Show InChI InChI=1S/C26H23ClFN3O3/c1-30-9-2-10-31(12-11-30)26(33)16-3-6-22(28)21(13-16)24-8-5-18(34-24)15-20-19-14-17(27)4-7-23(19)29-25(20)32/h3-8,13-15H,2,9-12H2,1H3,(H,29,32)/b20-15+ | PDB
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| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant Pim1 using RSRHSSYPAGT as substrate by radiometric assay |
ACS Med Chem Lett 3: 135-139 (2012)
Article DOI: 10.1021/ml200259q
BindingDB Entry DOI: 10.7270/Q2X92CBW |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM50384715
(CHEMBL2037201)Show SMILES Clc1ccc2NC(=O)\C(=C\c3ccc(o3)-c3cccc(c3)C(=O)N3CCCNCC3)c2c1 Show InChI InChI=1S/C25H22ClN3O3/c26-18-5-7-22-20(14-18)21(24(30)28-22)15-19-6-8-23(32-19)16-3-1-4-17(13-16)25(31)29-11-2-9-27-10-12-29/h1,3-8,13-15,27H,2,9-12H2,(H,28,30)/b21-15+ | PDB
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| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant Pim1 using RSRHSSYPAGT as substrate by radiometric assay |
ACS Med Chem Lett 3: 135-139 (2012)
Article DOI: 10.1021/ml200259q
BindingDB Entry DOI: 10.7270/Q2X92CBW |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM50384714
(CHEMBL2037200)Show SMILES CN1CCCN(CC1)C(=O)c1cccc(c1)-c1ccc(\C=C2\C(=O)Nc3ccc(Cl)cc23)o1 Show InChI InChI=1S/C26H24ClN3O3/c1-29-10-3-11-30(13-12-29)26(32)18-5-2-4-17(14-18)24-9-7-20(33-24)16-22-21-15-19(27)6-8-23(21)28-25(22)31/h2,4-9,14-16H,3,10-13H2,1H3,(H,28,31)/b22-16+ | PDB
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| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant Pim1 using RSRHSSYPAGT as substrate by radiometric assay |
ACS Med Chem Lett 3: 135-139 (2012)
Article DOI: 10.1021/ml200259q
BindingDB Entry DOI: 10.7270/Q2X92CBW |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50384706
(CHEMBL2037204)Show SMILES CN1CCCN(CC1)C(=O)c1ccc(F)c(c1)-c1ccc(\C=C2\C(=O)Nc3ccc(Cl)cc23)o1 Show InChI InChI=1S/C26H23ClFN3O3/c1-30-9-2-10-31(12-11-30)26(33)16-3-6-22(28)21(13-16)24-8-5-18(34-24)15-20-19-14-17(27)4-7-23(19)29-25(20)32/h3-8,13-15H,2,9-12H2,1H3,(H,29,32)/b20-15+ | PDB
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| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant Pim2 using RSRHSSYPAGT as substrate by radiometric assay |
ACS Med Chem Lett 3: 135-139 (2012)
Article DOI: 10.1021/ml200259q
BindingDB Entry DOI: 10.7270/Q2X92CBW |
More data for this
Ligand-Target Pair | |
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human)) | BDBM50335639
(7-((1H-tetrazol-5-yl)methyl)indolo[1,2-a]quinazoli...)Show SMILES O=c1[nH]c2c(Cc3nnn[nH]3)c3ccccc3n2c2ccccc12 Show InChI InChI=1S/C17H12N6O/c24-17-11-6-2-4-8-14(11)23-13-7-3-1-5-10(13)12(16(23)18-17)9-15-19-21-22-20-15/h1-8H,9H2,(H,18,24)(H,19,20,21,22) | PDB
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| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Cylene Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of PARP1 at 1 uM by chemiluminescence assay |
J Med Chem 54: 635-54 (2011)
Article DOI: 10.1021/jm101251q
BindingDB Entry DOI: 10.7270/Q2J67H7N |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-3
(Homo sapiens (Human)) | BDBM50384714
(CHEMBL2037200)Show SMILES CN1CCCN(CC1)C(=O)c1cccc(c1)-c1ccc(\C=C2\C(=O)Nc3ccc(Cl)cc23)o1 Show InChI InChI=1S/C26H24ClN3O3/c1-29-10-3-11-30(13-12-29)26(32)18-5-2-4-17(14-18)24-9-7-20(33-24)16-22-21-15-19(27)6-8-23(21)28-25(22)31/h2,4-9,14-16H,3,10-13H2,1H3,(H,28,31)/b22-16+ | KEGG
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| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of Pim3 using RSRHSSYPAGT as substrate by radiometric assay |
ACS Med Chem Lett 3: 135-139 (2012)
Article DOI: 10.1021/ml200259q
BindingDB Entry DOI: 10.7270/Q2X92CBW |
More data for this
Ligand-Target Pair | |
Death-associated protein kinase 3
(Homo sapiens (Human)) | BDBM50335638
(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)Show SMILES OC(=O)c1ccc2c(c1)nc(Nc1cccc(Cl)c1)c1ccncc21 Show InChI InChI=1S/C19H12ClN3O2/c20-12-2-1-3-13(9-12)22-18-15-6-7-21-10-16(15)14-5-4-11(19(24)25)8-17(14)23-18/h1-10H,(H,22,23)(H,24,25) | PDB
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| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Cylene Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant DAPK3 by radiometric assay |
J Med Chem 54: 635-54 (2011)
Article DOI: 10.1021/jm101251q
BindingDB Entry DOI: 10.7270/Q2J67H7N |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM50384717
(CHEMBL2037203)Show SMILES CN1CCCN(CC1)C(=O)c1ccc(Cl)c(c1)-c1ccc(\C=C2\C(=O)Nc3ccc(Cl)cc23)o1 Show InChI InChI=1S/C26H23Cl2N3O3/c1-30-9-2-10-31(12-11-30)26(33)16-3-6-22(28)21(13-16)24-8-5-18(34-24)15-20-19-14-17(27)4-7-23(19)29-25(20)32/h3-8,13-15H,2,9-12H2,1H3,(H,29,32)/b20-15+ | PDB
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| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant Pim1 using RSRHSSYPAGT as substrate by radiometric assay |
ACS Med Chem Lett 3: 135-139 (2012)
Article DOI: 10.1021/ml200259q
BindingDB Entry DOI: 10.7270/Q2X92CBW |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM50384709
(CHEMBL2037195)Show SMILES Clc1ccc2NC(=O)\C(=C\c3ccc(o3)-c3cccc(c3)C(=O)NCCN3CCCC3)c2c1 Show InChI InChI=1S/C26H24ClN3O3/c27-19-6-8-23-21(15-19)22(26(32)29-23)16-20-7-9-24(33-20)17-4-3-5-18(14-17)25(31)28-10-13-30-11-1-2-12-30/h3-9,14-16H,1-2,10-13H2,(H,28,31)(H,29,32)/b22-16+ | PDB
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| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant Pim1 using RSRHSSYPAGT as substrate by radiometric assay |
ACS Med Chem Lett 3: 135-139 (2012)
Article DOI: 10.1021/ml200259q
BindingDB Entry DOI: 10.7270/Q2X92CBW |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50384715
(CHEMBL2037201)Show SMILES Clc1ccc2NC(=O)\C(=C\c3ccc(o3)-c3cccc(c3)C(=O)N3CCCNCC3)c2c1 Show InChI InChI=1S/C25H22ClN3O3/c26-18-5-7-22-20(14-18)21(24(30)28-22)15-19-6-8-23(32-19)16-3-1-4-17(13-16)25(31)29-11-2-9-27-10-12-29/h1,3-8,13-15,27H,2,9-12H2,(H,28,30)/b21-15+ | PDB
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| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant Pim2 using RSRHSSYPAGT as substrate by radiometric assay |
ACS Med Chem Lett 3: 135-139 (2012)
Article DOI: 10.1021/ml200259q
BindingDB Entry DOI: 10.7270/Q2X92CBW |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50384714
(CHEMBL2037200)Show SMILES CN1CCCN(CC1)C(=O)c1cccc(c1)-c1ccc(\C=C2\C(=O)Nc3ccc(Cl)cc23)o1 Show InChI InChI=1S/C26H24ClN3O3/c1-29-10-3-11-30(13-12-29)26(32)18-5-2-4-17(14-18)24-9-7-20(33-24)16-22-21-15-19(27)6-8-23(21)28-25(22)31/h2,4-9,14-16H,3,10-13H2,1H3,(H,28,31)/b22-16+ | PDB
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| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant Pim2 using RSRHSSYPAGT as substrate by radiometric assay |
ACS Med Chem Lett 3: 135-139 (2012)
Article DOI: 10.1021/ml200259q
BindingDB Entry DOI: 10.7270/Q2X92CBW |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM50384713
(CHEMBL2037199)Show SMILES OCCCNC(=O)c1cccc(c1)-c1ccc(\C=C2\C(=O)Nc3ccc(Cl)cc23)o1 Show InChI InChI=1S/C23H19ClN2O4/c24-16-5-7-20-18(12-16)19(23(29)26-20)13-17-6-8-21(30-17)14-3-1-4-15(11-14)22(28)25-9-2-10-27/h1,3-8,11-13,27H,2,9-10H2,(H,25,28)(H,26,29)/b19-13+ | PDB
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| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant Pim1 using RSRHSSYPAGT as substrate by radiometric assay |
ACS Med Chem Lett 3: 135-139 (2012)
Article DOI: 10.1021/ml200259q
BindingDB Entry DOI: 10.7270/Q2X92CBW |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase TBK1
(Homo sapiens (Human)) | BDBM50335638
(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)Show SMILES OC(=O)c1ccc2c(c1)nc(Nc1cccc(Cl)c1)c1ccncc21 Show InChI InChI=1S/C19H12ClN3O2/c20-12-2-1-3-13(9-12)22-18-15-6-7-21-10-16(15)14-5-4-11(19(24)25)8-17(14)23-18/h1-10H,(H,22,23)(H,24,25) | PDB
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| n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
Cylene Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant TBK1 by radiometric assay |
J Med Chem 54: 635-54 (2011)
Article DOI: 10.1021/jm101251q
BindingDB Entry DOI: 10.7270/Q2J67H7N |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50384718
(CHEMBL2037205)Show SMILES CN1CCCN(CC1)C(=O)c1cccc(c1)-c1ccc(o1)C(C)=C1C(=O)Nc2ccc(Cl)cc12 Show InChI InChI=1S/C27H26ClN3O3/c1-17(25-21-16-20(28)7-8-22(21)29-26(25)32)23-9-10-24(34-23)18-5-3-6-19(15-18)27(33)31-12-4-11-30(2)13-14-31/h3,5-10,15-16H,4,11-14H2,1-2H3,(H,29,32) | PDB
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| n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant Pim2 using RSRHSSYPAGT as substrate by radiometric assay |
ACS Med Chem Lett 3: 135-139 (2012)
Article DOI: 10.1021/ml200259q
BindingDB Entry DOI: 10.7270/Q2X92CBW |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50384713
(CHEMBL2037199)Show SMILES OCCCNC(=O)c1cccc(c1)-c1ccc(\C=C2\C(=O)Nc3ccc(Cl)cc23)o1 Show InChI InChI=1S/C23H19ClN2O4/c24-16-5-7-20-18(12-16)19(23(29)26-20)13-17-6-8-21(30-17)14-3-1-4-15(11-14)22(28)25-9-2-10-27/h1,3-8,11-13,27H,2,9-10H2,(H,25,28)(H,26,29)/b19-13+ | PDB
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| n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant Pim2 using RSRHSSYPAGT as substrate by radiometric assay |
ACS Med Chem Lett 3: 135-139 (2012)
Article DOI: 10.1021/ml200259q
BindingDB Entry DOI: 10.7270/Q2X92CBW |
More data for this
Ligand-Target Pair | |
Dual specificity protein kinase CLK3
(Homo sapiens (Human)) | BDBM50335638
(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)Show SMILES OC(=O)c1ccc2c(c1)nc(Nc1cccc(Cl)c1)c1ccncc21 Show InChI InChI=1S/C19H12ClN3O2/c20-12-2-1-3-13(9-12)22-18-15-6-7-21-10-16(15)14-5-4-11(19(24)25)8-17(14)23-18/h1-10H,(H,22,23)(H,24,25) | PDB
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| n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
Cylene Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant CLK3 by radiometric assay |
J Med Chem 54: 635-54 (2011)
Article DOI: 10.1021/jm101251q
BindingDB Entry DOI: 10.7270/Q2J67H7N |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM50384708
(CHEMBL2037135)Show SMILES O=C(NCCN1CCCC1)c1cccc(c1)-c1ccc(\C=C2\C(=O)Nc3ccccc23)o1 Show InChI InChI=1S/C26H25N3O3/c30-25(27-12-15-29-13-3-4-14-29)19-7-5-6-18(16-19)24-11-10-20(32-24)17-22-21-8-1-2-9-23(21)28-26(22)31/h1-2,5-11,16-17H,3-4,12-15H2,(H,27,30)(H,28,31)/b22-17+ | PDB
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| n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant Pim1 using RSRHSSYPAGT as substrate by radiometric assay |
ACS Med Chem Lett 3: 135-139 (2012)
Article DOI: 10.1021/ml200259q
BindingDB Entry DOI: 10.7270/Q2X92CBW |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM50384711
(CHEMBL2037197)Show SMILES Clc1cccc2\C(=C/c3ccc(o3)-c3cccc(c3)C(=O)NCCN3CCCC3)C(=O)Nc12 Show InChI InChI=1S/C26H24ClN3O3/c27-22-8-4-7-20-21(26(32)29-24(20)22)16-19-9-10-23(33-19)17-5-3-6-18(15-17)25(31)28-11-14-30-12-1-2-13-30/h3-10,15-16H,1-2,11-14H2,(H,28,31)(H,29,32)/b21-16+ | PDB
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TBA
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant Pim1 using RSRHSSYPAGT as substrate by radiometric assay |
ACS Med Chem Lett 3: 135-139 (2012)
Article DOI: 10.1021/ml200259q
BindingDB Entry DOI: 10.7270/Q2X92CBW |
More data for this
Ligand-Target Pair | |
Homeodomain-interacting protein kinase 3
(Homo sapiens (Human)) | BDBM50335638
(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)Show SMILES OC(=O)c1ccc2c(c1)nc(Nc1cccc(Cl)c1)c1ccncc21 Show InChI InChI=1S/C19H12ClN3O2/c20-12-2-1-3-13(9-12)22-18-15-6-7-21-10-16(15)14-5-4-11(19(24)25)8-17(14)23-18/h1-10H,(H,22,23)(H,24,25) | PDB
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Cylene Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant HIPK3 by radiometric assay |
J Med Chem 54: 635-54 (2011)
Article DOI: 10.1021/jm101251q
BindingDB Entry DOI: 10.7270/Q2J67H7N |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM50335638
(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)Show SMILES OC(=O)c1ccc2c(c1)nc(Nc1cccc(Cl)c1)c1ccncc21 Show InChI InChI=1S/C19H12ClN3O2/c20-12-2-1-3-13(9-12)22-18-15-6-7-21-10-16(15)14-5-4-11(19(24)25)8-17(14)23-18/h1-10H,(H,22,23)(H,24,25) | PDB
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| n/a | n/a | 46 | n/a | n/a | n/a | n/a | n/a | n/a |
Cylene Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PIM1 by radiometric assay |
J Med Chem 54: 635-54 (2011)
Article DOI: 10.1021/jm101251q
BindingDB Entry DOI: 10.7270/Q2J67H7N |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50335638
(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)Show SMILES OC(=O)c1ccc2c(c1)nc(Nc1cccc(Cl)c1)c1ccncc21 Show InChI InChI=1S/C19H12ClN3O2/c20-12-2-1-3-13(9-12)22-18-15-6-7-21-10-16(15)14-5-4-11(19(24)25)8-17(14)23-18/h1-10H,(H,22,23)(H,24,25) | PDB
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| n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
Cylene Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant FLT3 by radiometric assay |
J Med Chem 54: 635-54 (2011)
Article DOI: 10.1021/jm101251q
BindingDB Entry DOI: 10.7270/Q2J67H7N |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 1/G2/mitotic-specific cyclin-B1/G2/mitotic-specific cyclin-B2/G2/mitotic-specific cyclin-B3
(Homo sapiens (Human)) | BDBM50335638
(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)Show SMILES OC(=O)c1ccc2c(c1)nc(Nc1cccc(Cl)c1)c1ccncc21 Show InChI InChI=1S/C19H12ClN3O2/c20-12-2-1-3-13(9-12)22-18-15-6-7-21-10-16(15)14-5-4-11(19(24)25)8-17(14)23-18/h1-10H,(H,22,23)(H,24,25) | PDB
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Cylene Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant CDK1/Cyclin B by radiometric assay |
J Med Chem 54: 635-54 (2011)
Article DOI: 10.1021/jm101251q
BindingDB Entry DOI: 10.7270/Q2J67H7N |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM50384718
(CHEMBL2037205)Show SMILES CN1CCCN(CC1)C(=O)c1cccc(c1)-c1ccc(o1)C(C)=C1C(=O)Nc2ccc(Cl)cc12 Show InChI InChI=1S/C27H26ClN3O3/c1-17(25-21-16-20(28)7-8-22(21)29-26(25)32)23-9-10-24(34-23)18-5-3-6-19(15-18)27(33)31-12-4-11-30(2)13-14-31/h3,5-10,15-16H,4,11-14H2,1-2H3,(H,29,32) | PDB
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TBA
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant Pim1 using RSRHSSYPAGT as substrate by radiometric assay |
ACS Med Chem Lett 3: 135-139 (2012)
Article DOI: 10.1021/ml200259q
BindingDB Entry DOI: 10.7270/Q2X92CBW |
More data for this
Ligand-Target Pair | |
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human)) | BDBM50335641
(4-Oxo-4,5-dihydrothieno[3,2-c]quinoline-7-carboxam...)Show InChI InChI=1S/C12H8N2O2S/c13-11(15)6-1-2-7-9(5-6)14-12(16)8-3-4-17-10(7)8/h1-5H,(H2,13,15)(H,14,16) | PDB
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Cylene Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of PARP1 by chemiluminescence assay |
J Med Chem 54: 635-54 (2011)
Article DOI: 10.1021/jm101251q
BindingDB Entry DOI: 10.7270/Q2J67H7N |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50384709
(CHEMBL2037195)Show SMILES Clc1ccc2NC(=O)\C(=C\c3ccc(o3)-c3cccc(c3)C(=O)NCCN3CCCC3)c2c1 Show InChI InChI=1S/C26H24ClN3O3/c27-19-6-8-23-21(15-19)22(26(32)29-23)16-20-7-9-24(33-20)17-4-3-5-18(14-17)25(31)28-10-13-30-11-1-2-12-30/h3-9,14-16H,1-2,10-13H2,(H,28,31)(H,29,32)/b22-16+ | PDB
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| n/a | n/a | 62 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant Pim2 using RSRHSSYPAGT as substrate by radiometric assay |
ACS Med Chem Lett 3: 135-139 (2012)
Article DOI: 10.1021/ml200259q
BindingDB Entry DOI: 10.7270/Q2X92CBW |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM50384716
(CHEMBL2037202)Show SMILES CN1CCCN(CC1)C(=O)c1cncc(n1)-c1ccc(\C=C2\C(=O)Nc3ccc(Cl)cc23)o1 Show InChI InChI=1S/C24H22ClN5O3/c1-29-7-2-8-30(10-9-29)24(32)21-14-26-13-20(27-21)22-6-4-16(33-22)12-18-17-11-15(25)3-5-19(17)28-23(18)31/h3-6,11-14H,2,7-10H2,1H3,(H,28,31)/b18-12+ | PDB
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TBA
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant Pim1 using RSRHSSYPAGT as substrate by radiometric assay |
ACS Med Chem Lett 3: 135-139 (2012)
Article DOI: 10.1021/ml200259q
BindingDB Entry DOI: 10.7270/Q2X92CBW |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM50384710
(CHEMBL2037196)Show SMILES Fc1ccc2NC(=O)\C(=C\c3ccc(o3)-c3cccc(c3)C(=O)NCCN3CCCC3)c2c1 Show InChI InChI=1S/C26H24FN3O3/c27-19-6-8-23-21(15-19)22(26(32)29-23)16-20-7-9-24(33-20)17-4-3-5-18(14-17)25(31)28-10-13-30-11-1-2-12-30/h3-9,14-16H,1-2,10-13H2,(H,28,31)(H,29,32)/b22-16+ | PDB
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| n/a | n/a | 74.4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant Pim1 using RSRHSSYPAGT as substrate by radiometric assay |
ACS Med Chem Lett 3: 135-139 (2012)
Article DOI: 10.1021/ml200259q
BindingDB Entry DOI: 10.7270/Q2X92CBW |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50384719
(CHEMBL2037206)Show SMILES CCC(=C1C(=O)Nc2ccc(Cl)cc12)c1ccc(o1)-c1cccc(c1)C(=O)N1CCCN(C)CC1 Show InChI InChI=1S/C28H28ClN3O3/c1-3-21(26-22-17-20(29)8-9-23(22)30-27(26)33)25-11-10-24(35-25)18-6-4-7-19(16-18)28(34)32-13-5-12-31(2)14-15-32/h4,6-11,16-17H,3,5,12-15H2,1-2H3,(H,30,33) | PDB
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TBA
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant Pim2 using RSRHSSYPAGT as substrate by radiometric assay |
ACS Med Chem Lett 3: 135-139 (2012)
Article DOI: 10.1021/ml200259q
BindingDB Entry DOI: 10.7270/Q2X92CBW |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50384712
(CHEMBL2037198)Show SMILES Fc1ccc2NC(=O)\C(=C\c3ccc(o3)-c3cccc(c3)C(=O)NC3CC3)c2c1 Show InChI InChI=1S/C23H17FN2O3/c24-15-4-8-20-18(11-15)19(23(28)26-20)12-17-7-9-21(29-17)13-2-1-3-14(10-13)22(27)25-16-5-6-16/h1-4,7-12,16H,5-6H2,(H,25,27)(H,26,28)/b19-12+ | PDB
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TBA
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant Pim2 using RSRHSSYPAGT as substrate by radiometric assay |
ACS Med Chem Lett 3: 135-139 (2012)
Article DOI: 10.1021/ml200259q
BindingDB Entry DOI: 10.7270/Q2X92CBW |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50384710
(CHEMBL2037196)Show SMILES Fc1ccc2NC(=O)\C(=C\c3ccc(o3)-c3cccc(c3)C(=O)NCCN3CCCC3)c2c1 Show InChI InChI=1S/C26H24FN3O3/c27-19-6-8-23-21(15-19)22(26(32)29-23)16-20-7-9-24(33-20)17-4-3-5-18(14-17)25(31)28-10-13-30-11-1-2-12-30/h3-9,14-16H,1-2,10-13H2,(H,28,31)(H,29,32)/b22-16+ | PDB
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TBA
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant Pim2 using RSRHSSYPAGT as substrate by radiometric assay |
ACS Med Chem Lett 3: 135-139 (2012)
Article DOI: 10.1021/ml200259q
BindingDB Entry DOI: 10.7270/Q2X92CBW |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM50384719
(CHEMBL2037206)Show SMILES CCC(=C1C(=O)Nc2ccc(Cl)cc12)c1ccc(o1)-c1cccc(c1)C(=O)N1CCCN(C)CC1 Show InChI InChI=1S/C28H28ClN3O3/c1-3-21(26-22-17-20(29)8-9-23(22)30-27(26)33)25-11-10-24(35-25)18-6-4-7-19(16-18)28(34)32-13-5-12-31(2)14-15-32/h4,6-11,16-17H,3,5,12-15H2,1-2H3,(H,30,33) | PDB
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| n/a | n/a | 131 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant Pim1 using RSRHSSYPAGT as substrate by radiometric assay |
ACS Med Chem Lett 3: 135-139 (2012)
Article DOI: 10.1021/ml200259q
BindingDB Entry DOI: 10.7270/Q2X92CBW |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50384714
(CHEMBL2037200)Show SMILES CN1CCCN(CC1)C(=O)c1cccc(c1)-c1ccc(\C=C2\C(=O)Nc3ccc(Cl)cc23)o1 Show InChI InChI=1S/C26H24ClN3O3/c1-29-10-3-11-30(13-12-29)26(32)18-5-2-4-17(14-18)24-9-7-20(33-24)16-22-21-15-19(27)6-8-23(21)28-25(22)31/h2,4-9,14-16H,3,10-13H2,1H3,(H,28,31)/b22-16+ | PDB
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| n/a | n/a | 134 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of Flt3 using EAIYAAPFAKKK as substrate by radiometric assay |
ACS Med Chem Lett 3: 135-139 (2012)
Article DOI: 10.1021/ml200259q
BindingDB Entry DOI: 10.7270/Q2X92CBW |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50384715
(CHEMBL2037201)Show SMILES Clc1ccc2NC(=O)\C(=C\c3ccc(o3)-c3cccc(c3)C(=O)N3CCCNCC3)c2c1 Show InChI InChI=1S/C25H22ClN3O3/c26-18-5-7-22-20(14-18)21(24(30)28-22)15-19-6-8-23(32-19)16-3-1-4-17(13-16)25(31)29-11-2-9-27-10-12-29/h1,3-8,13-15,27H,2,9-12H2,(H,28,30)/b21-15+ | PDB
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| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of Flt3 using EAIYAAPFAKKK as substrate by radiometric assay |
ACS Med Chem Lett 3: 135-139 (2012)
Article DOI: 10.1021/ml200259q
BindingDB Entry DOI: 10.7270/Q2X92CBW |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50384717
(CHEMBL2037203)Show SMILES CN1CCCN(CC1)C(=O)c1ccc(Cl)c(c1)-c1ccc(\C=C2\C(=O)Nc3ccc(Cl)cc23)o1 Show InChI InChI=1S/C26H23Cl2N3O3/c1-30-9-2-10-31(12-11-30)26(33)16-3-6-22(28)21(13-16)24-8-5-18(34-24)15-20-19-14-17(27)4-7-23(19)29-25(20)32/h3-8,13-15H,2,9-12H2,1H3,(H,29,32)/b20-15+ | PDB
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| Article
PubMed
| n/a | n/a | 217 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant Pim2 using RSRHSSYPAGT as substrate by radiometric assay |
ACS Med Chem Lett 3: 135-139 (2012)
Article DOI: 10.1021/ml200259q
BindingDB Entry DOI: 10.7270/Q2X92CBW |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50384716
(CHEMBL2037202)Show SMILES CN1CCCN(CC1)C(=O)c1cncc(n1)-c1ccc(\C=C2\C(=O)Nc3ccc(Cl)cc23)o1 Show InChI InChI=1S/C24H22ClN5O3/c1-29-7-2-8-30(10-9-29)24(32)21-14-26-13-20(27-21)22-6-4-16(33-22)12-18-17-11-15(25)3-5-19(17)28-23(18)31/h3-6,11-14H,2,7-10H2,1H3,(H,28,31)/b18-12+ | PDB
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UniChem
| Article
PubMed
| n/a | n/a | 225 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant Pim2 using RSRHSSYPAGT as substrate by radiometric assay |
ACS Med Chem Lett 3: 135-139 (2012)
Article DOI: 10.1021/ml200259q
BindingDB Entry DOI: 10.7270/Q2X92CBW |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM50384707
(CHEMBL2037133)Show SMILES OC(=O)c1cccc(c1)-c1ccc(\C=C2\C(=O)Nc3ccccc23)o1 Show InChI InChI=1S/C20H13NO4/c22-19-16(15-6-1-2-7-17(15)21-19)11-14-8-9-18(25-14)12-4-3-5-13(10-12)20(23)24/h1-11H,(H,21,22)(H,23,24)/b16-11+ | PDB
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UniChem
| Article
PubMed
| n/a | n/a | 386 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant Pim1 using RSRHSSYPAGT as substrate by radiometric assay |
ACS Med Chem Lett 3: 135-139 (2012)
Article DOI: 10.1021/ml200259q
BindingDB Entry DOI: 10.7270/Q2X92CBW |
More data for this
Ligand-Target Pair | |
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human)) | BDBM50335642
(7-(Hydroxymethyl)thieno[3,2-c]quinolin-4(5H)-one |...)Show InChI InChI=1S/C12H9NO2S/c14-6-7-1-2-8-10(5-7)13-12(15)9-3-4-16-11(8)9/h1-5,14H,6H2,(H,13,15) | PDB
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UniChem
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| Article
PubMed
| n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
Cylene Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of PARP1 by chemiluminescence assay |
J Med Chem 54: 635-54 (2011)
Article DOI: 10.1021/jm101251q
BindingDB Entry DOI: 10.7270/Q2J67H7N |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50384711
(CHEMBL2037197)Show SMILES Clc1cccc2\C(=C/c3ccc(o3)-c3cccc(c3)C(=O)NCCN3CCCC3)C(=O)Nc12 Show InChI InChI=1S/C26H24ClN3O3/c27-22-8-4-7-20-21(26(32)29-24(20)22)16-19-9-10-23(33-19)17-5-3-6-18(15-17)25(31)28-11-14-30-12-1-2-13-30/h3-10,15-16H,1-2,11-14H2,(H,28,31)(H,29,32)/b21-16+ | PDB
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UniChem
Similars
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| n/a | n/a | 445 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant Pim2 using RSRHSSYPAGT as substrate by radiometric assay |
ACS Med Chem Lett 3: 135-139 (2012)
Article DOI: 10.1021/ml200259q
BindingDB Entry DOI: 10.7270/Q2X92CBW |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM50384712
(CHEMBL2037198)Show SMILES Fc1ccc2NC(=O)\C(=C\c3ccc(o3)-c3cccc(c3)C(=O)NC3CC3)c2c1 Show InChI InChI=1S/C23H17FN2O3/c24-15-4-8-20-18(11-15)19(23(28)26-20)12-17-7-9-21(29-17)13-2-1-3-14(10-13)22(27)25-16-5-6-16/h1-4,7-12,16H,5-6H2,(H,25,27)(H,26,28)/b19-12+ | PDB
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UniChem
Similars
| Article
PubMed
| n/a | n/a | 506 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant Pim1 using RSRHSSYPAGT as substrate by radiometric assay |
ACS Med Chem Lett 3: 135-139 (2012)
Article DOI: 10.1021/ml200259q
BindingDB Entry DOI: 10.7270/Q2X92CBW |
More data for this
Ligand-Target Pair | |
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human)) | BDBM50335640
(4-Oxo-4,5-dihydrothieno[3,2-c]quinoline-7-carboxyl...)Show InChI InChI=1S/C12H7NO3S/c14-11-8-3-4-17-10(8)7-2-1-6(12(15)16)5-9(7)13-11/h1-5H,(H,13,14)(H,15,16) | PDB
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UniChem
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| n/a | n/a | 700 | n/a | n/a | n/a | n/a | n/a | n/a |
Cylene Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of PARP1 by chemiluminescence assay |
J Med Chem 54: 635-54 (2011)
Article DOI: 10.1021/jm101251q
BindingDB Entry DOI: 10.7270/Q2J67H7N |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-3
(Homo sapiens (Human)) | BDBM50384715
(CHEMBL2037201)Show SMILES Clc1ccc2NC(=O)\C(=C\c3ccc(o3)-c3cccc(c3)C(=O)N3CCCNCC3)c2c1 Show InChI InChI=1S/C25H22ClN3O3/c26-18-5-7-22-20(14-18)21(24(30)28-22)15-19-6-8-23(32-19)16-3-1-4-17(13-16)25(31)29-11-2-9-27-10-12-29/h1,3-8,13-15,27H,2,9-12H2,(H,28,30)/b21-15+ | KEGG
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UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of Pim3 using RSRHSSYPAGT as substrate by radiometric assay |
ACS Med Chem Lett 3: 135-139 (2012)
Article DOI: 10.1021/ml200259q
BindingDB Entry DOI: 10.7270/Q2X92CBW |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50384714
(CHEMBL2037200)Show SMILES CN1CCCN(CC1)C(=O)c1cccc(c1)-c1ccc(\C=C2\C(=O)Nc3ccc(Cl)cc23)o1 Show InChI InChI=1S/C26H24ClN3O3/c1-29-10-3-11-30(13-12-29)26(32)18-5-2-4-17(14-18)24-9-7-20(33-24)16-22-21-15-19(27)6-8-23(21)28-25(22)31/h2,4-9,14-16H,3,10-13H2,1H3,(H,28,31)/b22-16+ | PDB
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of Flt3 phosphorylation at Y591 in human MV411 cells after 2 hrs by Western blot analysis |
ACS Med Chem Lett 3: 135-139 (2012)
Article DOI: 10.1021/ml200259q
BindingDB Entry DOI: 10.7270/Q2X92CBW |
More data for this
Ligand-Target Pair | |
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