| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase pim-2 |
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| Ligand | BDBM50384719 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_820888 (CHEMBL2038829) |
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| IC50 | 82±n/a nM |
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| Citation |  Haddach, M; Michaux, J; Schwaebe, MK; Pierre, F; Borsan, C; Tran, J; Raffaele, N; Ravula, S; Drygin, D; Siddiqui-Jain, A; Darjania, L; Stansfield, R; Proffitt, C; Macalino, D; Streiner, N; Bliesath, J; Omori, M; Whitten, JP; Anderes, K; Rice, WG; Ryckman, DM Discovery of CX-6258. A Potent, Selective, and Orally Efficacious pan-Pim Kinases Inhibitor. ACS Med Chem Lett3:135-139 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase pim-2 |
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| Name: | Serine/threonine-protein kinase pim-2 |
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| Synonyms: | PIM2 | PIM2_HUMAN | Pim-2h | Serine/threonine-protein kinase (PIM2) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase pim-2 (PIM2) |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 34185.93 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9P1W9 |
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| Residue: | 311 |
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| Sequence: | MLTKPLQGPPAPPGTPTPPPGGKDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAI
KVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPL
PAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKL
IDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFER
DQEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNPSKG
GPAPLAWSLLP
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| BDBM50384719 |
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| n/a |
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| Name | BDBM50384719 |
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| Synonyms: | CHEMBL2037206 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H28ClN3O3 |
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| Mol. Mass. | 489.993 |
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| SMILES | CCC(=C1C(=O)Nc2ccc(Cl)cc12)c1ccc(o1)-c1cccc(c1)C(=O)N1CCCN(C)CC1 |
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| Structure | 
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