| Reaction Details |
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 | Report a problem with these data |
| Target | Lysosomal alpha-glucosidase |
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| Ligand | BDBM50394352 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_857276 (CHEMBL2160771) |
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| IC50 | >236000±n/a nM |
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| Citation |  Tanabe, G; Matsuoka, K; Yoshinaga, M; Xie, W; Tsutsui, N; A Amer, MF; Nakamura, S; Nakanishi, I; Wu, X; Yoshikawa, M; Muraoka, O Role of the side chain stereochemistry in thea-glucosidase inhibitory activity of kotalanol, a potent naturala-glucosidase inhibitor. Part 2. Bioorg Med Chem20:6321-34 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Lysosomal alpha-glucosidase |
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| Name: | Lysosomal alpha-glucosidase |
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| Synonyms: | Acidic alpha-glucosidase | Gaa | LYAG_RAT |
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| Type: | PROTEIN |
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| Mol. Mass.: | 106191.24 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_1506157 |
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| Residue: | 953 |
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| Sequence: | MNIRKPLCSNSVVGACTLVSLTTAVILGHLMLRELMLLPQDLHESSSGLWKTYRPHHQES
YEPAPLHIQEHAEQLRAVPTQCDVTPNSRFDCAPDKGITQEQCEARGCCWVPAGQVLNGP
VMGQPWCFFPPSYPSYRLENLSSTESGYTATLTRTSPTFFPKDVLTLQLEVLMETDSRLH
FMIKDPTSKRYEVPLETPRVLSQAPSPLYSVEFSEEPFGVIVRRKLGGRVLLNTTVAPLF
FADQFLQLSTSLPSQHIAGLGEHLSPLMLSTEWTRITLWNRDVAPSQGVNLYGSHPFYLA
LEDGGLAHGVFLLNSNAMDVVLQPSPALTWRSTGGILDVYVFLGPEPKSVVQQYLDVVGY
PFMPPYWGLGFHLCRWGYSSTAIVRQVVENMTRTHFPLDVQWNDLDYMDARRDFTFNQDG
FADFPDMVHELHQGGRRYMMIVDPAISSSGPAGSYRPYDEGLRRGVFITNETGQPLIGKV
WPGSTAFPDFTNPETLDWWQDMVSEFHAQVPFDGMWIDMNEPSNFIRGSQQGCPDNELEN
PPYVPGVVGGALQAATICASSHQFLSTHYNLHNLYGLTEAIASSRALVKTRGTRPFVISR
STFAGHGRYAGHWTGDVWSSWEHLAYSVPEILQFNLLGVPLVGADICGFQGNTTEELCVR
WTQLGAFYPFMRNHNDLNSLPQEPYRFSETAQQAMRKAFTLRYALLPYLYTLFHGAHVKG
DTVARPLFLEFPEDPSTWSVDRQLLWGPALLITPVLEPGKTDVTGYFPKGMWYNLQMVPV
ETLGSLPSSSPASSFRSIVHSKGQWLTLEAPLDTINVHLRAGYIIPLQGPSLTTTESRKQ
PMALAVALTESGEASGELFWDDGESLGVLERGAYTLVTFSAKNNTIVNKLVHVTKEGGEL
QLREVTILGVTTAPTQVLSNGISVSNFTYSPDDKSLSIPVSLLMGERFQIDWS
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| BDBM50394352 |
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| n/a |
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| Name | BDBM50394352 |
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| Synonyms: | CHEMBL2159631 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H24O12S2 |
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| Mol. Mass. | 424.442 |
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| SMILES | OC[C@H](O)[C@@H](O)[C@H](O)[C@H](OS([O-])(=O)=O)[C@H](O)C[S@@+]1C[C@@H](O)[C@H](O)[C@H]1CO |r| |
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| Structure | 
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