| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosyl-DNA phosphodiesterase 1 |
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| Ligand | BDBM26640 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_864727 (CHEMBL2174994) |
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| IC50 | >333000±n/a nM |
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| Citation |  Sirivolu, VR; Vernekar, SK; Marchand, C; Naumova, A; Chergui, A; Renaud, A; Stephen, AG; Chen, F; Sham, YY; Pommier, Y; Wang, Z 5-Arylidenethioxothiazolidinones as inhibitors of tyrosyl-DNA phosphodiesterase I. J Med Chem55:8671-84 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosyl-DNA phosphodiesterase 1 |
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| Name: | Tyrosyl-DNA phosphodiesterase 1 |
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| Synonyms: | TDP1 | TYDP1_HUMAN | Tyrosyl-DNA phosphodiesterase 1 | Tyrosyl-DNA phosphodiesterase 1 (TDP1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 68430.66 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9NUW8 |
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| Residue: | 608 |
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| Sequence: | MSQEGDYGRWTISSSDESEEEKPKPDKPSTSSLLCARQGAANEPRYTCSEAQKAAHKRKI
SPVKFSNTDSVLPPKRQKSGSQEDLGWCLSSSDDELQPEMPQKQAEKVVIKKEKDISAPN
DGTAQRTENHGAPACHRLKEEEDEYETSGEGQDIWDMLDKGNPFQFYLTRVSGVKPKYNS
GALHIKDILSPLFGTLVSSAQFNYCFDVDWLVKQYPPEFRKKPILLVHGDKREAKAHLHA
QAKPYENISLCQAKLDIAFGTHHTKMMLLLYEEGLRVVIHTSNLIHADWHQKTQGIWLSP
LYPRIADGTHKSGESPTHFKADLISYLMAYNAPSLKEWIDVIHKHDLSETNVYLIGSTPG
RFQGSQKDNWGHFRLKKLLKDHASSMPNAESWPVVGQFSSVGSLGADESKWLCSEFKESM
LTLGKESKTPGKSSVPLYLIYPSVENVRTSLEGYPAGGSLPYSIQTAEKQNWLHSYFHKW
SAETSGRSNAMPHIKTYMRPSPDFSKIAWFLVTSANLSKAAWGALEKNGTQLMIRSYELG
VLFLPSAFGLDSFKVKQKFFAGSQEPMATFPVPYDLPPELYGSKDRPWIWNIPYVKAPDT
HGNMWVPS
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| BDBM26640 |
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| n/a |
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| Name | BDBM26640 |
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| Synonyms: | (5Z)-5-[(4-fluorophenyl)methylidene]-1,3-thiazolidine-2,4-dione | thiazolidine-2,4-dione, 18a |
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| Type | Small organic molecule |
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| Emp. Form. | C10H6FNO2S |
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| Mol. Mass. | 223.224 |
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| SMILES | OC1=NC(=O)C(S1)=Cc1ccc(F)cc1 |w:7.8,t:1| |
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| Structure | 
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