Reaction Details | |||
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Target | Activated CDC42 kinase 1 | ||
Ligand | BDBM98294 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_939163 (CHEMBL2329235) | ||
IC50 | 84±n/a nM | ||
Citation | Jin, M; Wang, J; Kleinberg, A; Kadalbajoo, M; Siu, KW; Cooke, A; Bittner, MA; Yao, Y; Thelemann, A; Ji, Q; Bhagwat, S; Mulvihill, KM; Rechka, JA; Pachter, JA; Crew, AP; Epstein, D; Mulvihill, MJ Discovery of potent, selective and orally bioavailable imidazo[1,5-a]pyrazine derived ACK1 inhibitors. Bioorg Med Chem Lett23:979-84 (2013) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Activated CDC42 kinase 1 | |||
Name: | Activated CDC42 kinase 1 | ||
Synonyms: | ACK1 | ACK1_HUMAN | Activated CDC42 kinase 1 (ACK-1) | TNK2 | Tyrosine kinase non-receptor protein 2 | ||
Type: | Protein | ||
Mol. Mass.: | 114577.86 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q07912 | ||
Residue: | 1038 | ||
Sequence: |
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BDBM98294 | |||
n/a | |||
Name | BDBM98294 | ||
Synonyms: | US8481733, 106 | ||
Type | Small organic molecule | ||
Emp. Form. | C25H26N4O2 | ||
Mol. Mass. | 414.4995 | ||
SMILES | CC(O)(c1ccccc1)c1ccc(cc1)-c1nc([C@H]2C[C@@](C)(O)C2)n2ccnc(N)c12 |r,wU:18.19,20.23,wD:20.22,(.63,7.08,;.63,5.54,;-.46,6.63,;2.12,5.94,;3.21,4.85,;4.7,5.25,;5.09,6.74,;4.01,7.83,;2.52,7.43,;.23,4.05,;1.32,2.96,;.92,1.48,;-.56,1.08,;-1.65,2.17,;-1.25,3.65,;-.96,-.41,;-.06,-1.65,;-.96,-2.9,;-.56,-4.39,;.77,-5.16,;-0,-6.49,;1.33,-7.26,;-.77,-7.83,;-1.33,-5.72,;-2.43,-2.42,;-3.76,-3.19,;-5.09,-2.42,;-5.09,-.88,;-3.76,-.11,;-3.76,1.43,;-2.43,-.88,)| | ||
Structure |