Reaction Details |
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Target | Tyrosine-protein kinase Yes |
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Ligand | BDBM50428742 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_947984 (CHEMBL2344634) |
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IC50 | 496±n/a nM |
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Citation | Lafleur, K; Dong, J; Huang, D; Caflisch, A; Nevado, C Optimization of inhibitors of the tyrosine kinase EphB4. 2. Cellular potency improvement and binding mode validation by X-ray crystallography. J Med Chem56:84-96 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein kinase Yes |
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Name: | Tyrosine-protein kinase Yes |
Synonyms: | Proto-oncogene c-Yes | VHL/Tyrosine-protein kinase Yes | YES | YES1 | YES_HUMAN | p61-yes |
Type: | Protein |
Mol. Mass.: | 60801.54 |
Organism: | Homo sapiens (Human) |
Description: | P07947 |
Residue: | 543 |
Sequence: | MGCIKSKENKSPAIKYRPENTPEPVSTSVSHYGAEPTTVSPCPSSSAKGTAVNFSSLSMT
PFGGSSGVTPFGGASSSFSVVPSSYPAGLTGGVTIFVALYDYEARTTEDLSFKKGERFQI
INNTEGDWWEARSIATGKNGYIPSNYVAPADSIQAEEWYFGKMGRKDAERLLLNPGNQRG
IFLVRESETTKGAYSLSIRDWDEIRGDNVKHYKIRKLDNGGYYITTRAQFDTLQKLVKHY
TEHADGLCHKLTTVCPTVKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTT
KVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEPIYIVTEFMSKGSLLDFL
KEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLVCKIADFGLARL
IEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNRE
VLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLEDYFTATEPQYQPG
ENL
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BDBM50428742 |
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n/a |
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Name | BDBM50428742 |
Synonyms: | CHEMBL2333595 |
Type | Small organic molecule |
Emp. Form. | C19H20FN5O2 |
Mol. Mass. | 369.3928 |
SMILES | CCCCn1c(cn2c1nc1n(C)c(=O)[nH]c(=O)c21)-c1ccc(F)cc1C |
Structure |
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