Reaction Details |
| Report a problem with these data |
Target | Methionine aminopeptidase 1 |
---|
Ligand | BDBM50433374 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_957177 (CHEMBL2378715) |
---|
EC50 | 4800±n/a nM |
---|
Citation | Zhang, F; Bhat, S; Gabelli, SB; Chen, X; Miller, MS; Nacev, BA; Cheng, YL; Meyers, DJ; Tenney, K; Shim, JS; Crews, P; Amzel, LM; Ma, D; Liu, JO Pyridinylquinazolines selectively inhibit human methionine aminopeptidase-1 in cells. J Med Chem56:3996-4016 (2013) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Methionine aminopeptidase 1 |
---|
Name: | Methionine aminopeptidase 1 |
Synonyms: | Aminopeptidase | KIAA0094 | MAP 1 | MAP11_HUMAN | METAP1 | MetAP 1 | Methionine Aminopeptidase Type 1 (MetAP1) | Peptidase M 1 |
Type: | Enzyme |
Mol. Mass.: | 43220.79 |
Organism: | Homo sapiens (Human) |
Description: | MetAP1 with an N-terminal six histidine tag was expressed in baculovirus infected sf9 cells. |
Residue: | 386 |
Sequence: | MAAVETRVCETDGCSSEAKLQCPTCIKLGIQGSYFCSQECFKGSWATHKLLHKKAKDEKA
KREVSSWTVEGDINTDPWAGYRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQ
ALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCY
PSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGE
VDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLF
HTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHT
LLVTDTGCEILTRRLDSARPHFMSQF
|
|
|
BDBM50433374 |
---|
n/a |
---|
Name | BDBM50433374 |
Synonyms: | CHEMBL2375610 |
Type | Small organic molecule |
Emp. Form. | C25H24N6O2S |
Mol. Mass. | 472.562 |
SMILES | CC(=O)Nc1ncc(CC(=O)N2CCN(CC2)c2cc(nc3ccccc23)-c2ccccn2)s1 |
Structure |
|