| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cytochrome P450 2D6 |
|---|
| Ligand | BDBM50448619 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1296351 (CHEMBL3129761) |
|---|
| IC50 | >10000±n/a nM |
|---|
| Citation |  Giannetti, AM; Zheng, X; Skelton, NJ; Wang, W; Bravo, BJ; Bair, KW; Baumeister, T; Cheng, E; Crocker, L; Feng, Y; Gunzner-Toste, J; Ho, YC; Hua, R; Liederer, BM; Liu, Y; Ma, X; O'Brien, T; Oeh, J; Sampath, D; Shen, Y; Wang, C; Wang, L; Wu, H; Xiao, Y; Yuen, PW; Zak, M; Zhao, G; Zhao, Q; Dragovich, PS Fragment-based identification of amides derived from trans-2-(pyridin-3-yl)cyclopropanecarboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). J Med Chem57:770-92 (2014) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cytochrome P450 2D6 |
|---|
| Name: | Cytochrome P450 2D6 |
|---|
| Synonyms: | CP2D6_HUMAN | CYP2D6 | CYP2DL1 | CYPIID6 | Cytochrome P450 2D6 (CYP2D6) | Debrisoquine 4-hydroxylase | P450-DB1 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 55774.82 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P10635 |
|---|
| Residue: | 497 |
|---|
| Sequence: | MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ
LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF
LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK
AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV
LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA
DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI
HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF
LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV
FAFLVSPSPYELCAVPR
|
|
|
|---|
| BDBM50448619 |
|---|
| n/a |
|---|
| Name | BDBM50448619 |
|---|
| Synonyms: | CHEMBL3127525 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H23N3O4S |
|---|
| Mol. Mass. | 413.49 |
|---|
| SMILES | O=C(Nc1ccc(cc1)S(=O)(=O)N1CC2CCC(C1)O2)[C@@H]1C[C@H]1c1cccnc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
