| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein phosphatase non-receptor type 11 |
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| Ligand | BDBM50054265 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1458320 (CHEMBL3369282) |
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| IC50 | 3600±n/a nM |
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| Citation |  Zeng, LF; Zhang, RY; Yu, ZH; Li, S; Wu, L; Gunawan, AM; Lane, BS; Mali, RS; Li, X; Chan, RJ; Kapur, R; Wells, CD; Zhang, ZY Therapeutic potential of targeting the oncogenic SHP2 phosphatase. J Med Chem57:6594-609 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein phosphatase non-receptor type 11 |
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| Name: | Tyrosine-protein phosphatase non-receptor type 11 |
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| Synonyms: | 3.1.3.48 | PTN11_HUMAN | PTP-1D | PTP-2C | PTP2C | PTPN11 | Protein Tyrosine Phosphatase PPN11/Shp2 | Protein tyrosine phosphatase (PTP) Shp2 | Protein-Tyrosine Phosphatase SHP-2 | Protein-tyrosine phosphatase 1D | Protein-tyrosine phosphatase 2C | SH-PTP2 | SH-PTP3 | SHP-2 | SHP2 | SHPTP2 | Src homology phosphatase 2 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) | Tyrosine-protein phosphatase non-receptor type 11 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (SHP2) |
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| Type: | Protein phosphatase |
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| Mol. Mass.: | 68443.59 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q06124 |
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| Residue: | 593 |
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| Sequence: | MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTG
DYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGK
EAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYD
VGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETT
DKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEP
VSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEV
ERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHF
RTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIR
EKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGH
EYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
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| BDBM50054265 |
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| n/a |
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| Name | BDBM50054265 |
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| Synonyms: | CHEMBL3319384 | US9522881, 11c-2 (L88M49) |
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| Type | Small organic molecule |
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| Emp. Form. | C32H26IN3O6 |
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| Mol. Mass. | 675.4698 |
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| SMILES | Cn1c(c(I)c2cc(C(O)=O)c(O)cc12)-c1cccc(NC(=O)CCC(=O)Nc2ccc(Oc3ccccc3)cc2)c1 |
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| Structure | 
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