| Reaction Details |
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 | Report a problem with these data |
| Target | Cathepsin G |
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| Ligand | BDBM50072317 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1469016 (CHEMBL3412832) |
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| IC50 | 6000±n/a nM |
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| Citation |  Beaulieu, PL; Bolger, G; Deon, D; Duplessis, M; Fazal, G; Gagnon, A; Garneau, M; LaPlante, S; Stammers, T; Kukolj, G; Duan, J Multi-parameter optimization of aza-follow-ups to BI 207524, a thumb pocket 1 HCV NS5B polymerase inhibitor. Part 2: Impact of lipophilicity on promiscuity and in vivo toxicity. Bioorg Med Chem Lett25:1140-5 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cathepsin G |
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| Name: | Cathepsin G |
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| Synonyms: | CATG_HUMAN | CG | CTSG |
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| Type: | PROTEIN |
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| Mol. Mass.: | 28860.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1469016 |
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| Residue: | 255 |
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| Sequence: | MQPLLLLLAFLLPTGAEAGEIIGGRESRPHSRPYMAYLQIQSPAGQSRCGGFLVREDFVL
TAAHCWGSNINVTLGAHNIQRRENTQQHITARRAIRHPQYNQRTIQNDIMLLQLSRRVRR
NRNVNPVALPRAQEGLRPGTLCTVAGWGRVSMRRGTDTLREVQLRVQRDRQCLRIFGSYD
PRRQICVGDRRERKAAFKGDSGGPLLCNNVAHGIVSYGKSSGVPPEVFTRVSSFLPWIRT
TMRSFKLLDQMETPL
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| BDBM50072317 |
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| n/a |
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| Name | BDBM50072317 |
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| Synonyms: | CHEMBL3408841 |
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| Type | Small organic molecule |
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| Emp. Form. | C34H36FN5O5 |
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| Mol. Mass. | 613.6785 |
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| SMILES | CCOc1nc(NC(=O)C(C)(C)NC(=O)c2ccc3c(C4CCCC4)c(-c4ccc(F)cn4)n(C)c3c2)ccc1\C=C\C(O)=O |
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| Structure | 
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