| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium- and chloride-dependent GABA transporter 2 |
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| Ligand | BDBM50419338 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1454197 (CHEMBL3363497) |
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| IC50 | 6200±n/a nM |
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| Citation |  Kobayashi, T; Suemasa, A; Igawa, A; Ide, S; Fukuda, H; Abe, H; Arisawa, M; Minami, M; Shuto, S Conformationally Restricted GABA with Bicyclo[3.1.0]hexane Backbone as the First Highly Selective BGT-1 Inhibitor. ACS Med Chem Lett5:889-93 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium- and chloride-dependent GABA transporter 2 |
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| Name: | Sodium- and chloride-dependent GABA transporter 2 |
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| Synonyms: | GABA transporter 2 | GAT2 | S6A13_HUMAN | SLC6A13 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 68012.63 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1454197 |
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| Residue: | 602 |
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| Sequence: | MDSRVSGTTSNGETKPVYPVMEKKEEDGTLERGHWNNKMEFVLSVAGEIIGLGNVWRFPY
LCYKNGGGAFFIPYLVFLFTCGIPVFLLETALGQYTSQGGVTAWRKICPIFEGIGYASQM
IVILLNVYYIIVLAWALFYLFSSFTIDLPWGGCYHEWNTEHCMEFQKTNGSLNGTSENAT
SPVIEFWERRVLKISDGIQHLGALRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATF
PYLMLVVLLIRGVTLPGAAQGIQFYLYPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTAL
GSYNKYHNNCYRDCIALCFLNSGTSFVAGFAIFSILGFMSQEQGVPISEVAESGPGLAFI
AYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALVDMYPHVFRKKNRREVLI
LGVSVVSFLVGLIMLTEGGMYVFQLFDYYAASGMCLLFVAIFESLCVAWVYGAKRFYDNI
EDMIGYRPWPLIKYCWLFLTPAVCTATFLFSLIKYTPLTYNKKYTYPWWGDALGWLLALS
SMVCIPAWSLYRLGTLKGPFRERIRQLMCPAEDLPQRNPAGPSAPATPRTSLLRLTELES
HC
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| BDBM50419338 |
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| n/a |
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| Name | BDBM50419338 |
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| Synonyms: | CHEMBL1446457 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H30N2O2 |
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| Mol. Mass. | 414.5393 |
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| SMILES | COc1ccccc1C1(O)CCN(CCCn2c3ccccc3c3ccccc23)CC1 |
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| Structure | 
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